Library Of American University Of Madaba
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Escribano Cuesta, Ana.
New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids [electronic resource] / by Ana Escribano Cuesta. - XIII, 195 p. 280 illus., 41 illus. in color. online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053 .
Introduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
9783319007021
Chemistry.
Chemistry, Organic.
Catalysis.
Chemistry.
Organometallic Chemistry.
Catalysis.
Organic Chemistry.
QD410-412.5
547.05
New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids [electronic resource] / by Ana Escribano Cuesta. - XIII, 195 p. 280 illus., 41 illus. in color. online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053 .
Introduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
9783319007021
Chemistry.
Chemistry, Organic.
Catalysis.
Chemistry.
Organometallic Chemistry.
Catalysis.
Organic Chemistry.
QD410-412.5
547.05