Library of American University of Madaba
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Ehlert, Frederick J.,
Affinity and efficacy : the components of drug-receptor interactions / Components of drug-receptor interactions Frederick J. Ehlert. - Singapore : World Scientific, 2015. - ix, 739 p. : ill. ; 24 cm.
Includes bibliographical references.
Ligand-gated ion channels -- Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- Competitive interactions between orthostheric ligands at ligand-gated ion channels -- Analysis of allosteric interactions at ligand-gated ion channels -- G protein-coupled receptors and G protein signaling -- Affinity and efficacy of the agonist-receptor-G-protein interaction -- Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- Analysis of ligand bias in receptor signaling through different G protein pathways -- Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- Analysis of allosterism in functional assays on G protein-coupled receptors -- Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors.
9789814322560 (hardback : alk. paper) 9814322563 (hardback : alk. paper)
Drug receptors.
Pharmaceutical chemistry.
Drug receptors.
Ligand-Gated Ion Channels.
Protein Binding.
Radioligand Assay.
Receptors, G-Protein-Coupled.
615.70452 / E332
Affinity and efficacy : the components of drug-receptor interactions / Components of drug-receptor interactions Frederick J. Ehlert. - Singapore : World Scientific, 2015. - ix, 739 p. : ill. ; 24 cm.
Includes bibliographical references.
Ligand-gated ion channels -- Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- Competitive interactions between orthostheric ligands at ligand-gated ion channels -- Analysis of allosteric interactions at ligand-gated ion channels -- G protein-coupled receptors and G protein signaling -- Affinity and efficacy of the agonist-receptor-G-protein interaction -- Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- Analysis of ligand bias in receptor signaling through different G protein pathways -- Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- Analysis of allosterism in functional assays on G protein-coupled receptors -- Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors.
9789814322560 (hardback : alk. paper) 9814322563 (hardback : alk. paper)
Drug receptors.
Pharmaceutical chemistry.
Drug receptors.
Ligand-Gated Ion Channels.
Protein Binding.
Radioligand Assay.
Receptors, G-Protein-Coupled.
615.70452 / E332