Handbook of analysis of oligonucleotides and related products / edited by Jose V. Bonilla, Susan Srivatsa. - Boca Raton, FL : CRC Press, 2011. - xiv, 497 p. ; 27 cm.

Includes bibliographical references and index.

Purity analysis and impurities determination by reversed-phase HPLC / Hagen Cramer, Eric Herzberg & Kevin Finn -- Purity analysis and impurities determination by AEX-HPLC / J.R. Thayer, Veeravagu Murugaiah, Yansheng Wu -- Purity analysis and molecular weight determination by size exclusion HPLC analysis / Ming Fai Chan & Ipsita Roymoulik -- Analysis of oligonucleotides by liquid chromatography & mass spectrometry / Soheil Pourshahian & Sean McCarthy -- Sequence determination and confirmation by MS/MS and MALDI-TOF / Zoltan Timar -- Determination of melt temperature (TM) of oligonucleotides / Huihe Zhu & G. Susan Srivatsa -- Purity and content analysis of oligonucleotides by capillary gel electrophoresis / Judy Carmody and Bernhard Noll -- Bioanalysis of therapeutic oligonucleotides using hybridization-based immunoassay techniques / Sandra Carriero & Helen Legakis -- Oligonucleotide assay and potency / Dennis Michaud -- Microbial analysis : endotoxin testing / Barbara J. Markley -- Analysis of residual solvents by headspace gas chromatography / Sky Countryman & Jose V. Bonilla -- Determination of extinction coefficient / Veeravagu Murugaiah -- Structural determination by NMR / Michele L. Derider, Doug Brooks & Gary Burt -- Infrared analysis of oligonucleotides / Jose V. Bonilla -- Stability indicating methods for oligonucleotide products / Veeravagu Murugaiah -- Analysis by hydrophilic interaction chromatography (HILIC) / Patrick Limbach and Renee N. Easter -- Determination of base composition / H�useyin Ayg�un -- Analysis of metals in oligonucleotides / Mike Murphy -- Regulatory considerations for the development of oligonucleotide therapeutics / G. Susan Srivatsa.

9781439819937 (hardcover : alk. paper)


Oligonucleotides--Analysis.
Oligonucleotides--analysis.

QP625.O47 / H36 2011

572.85 / H36