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Molecularly Targeted Therapy for Childhood Cancer (Record no. 17137)

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003 - CONTROL NUMBER IDENTIFIER
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005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150232.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
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008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 100917s2010 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780387690629
978-0-387-69062-9
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC261-271
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
264 #1 -
-- New York, NY :
-- Springer New York :
-- Imprint: Springer,
-- 2010.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Houghton, Peter J.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Molecularly Targeted Therapy for Childhood Cancer
Medium [electronic resource] /
Statement of responsibility, etc edited by Peter J. Houghton, Robert J. Arceci.
300 ## - PHYSICAL DESCRIPTION
Extent XVIII, 538p. 23 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Hematologic Malignancies -- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia -- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia -- Molecularly Targeted Therapy for Infant ALL -- Targeted Therapeutic Approaches for AML -- Acute Promyelocytic Leukaemia -- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy -- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML) -- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics -- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes -- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma -- Molecular Targeting of Post-transplant Lymphoproliferative Disorders -- Solid Tumors -- Molecularly Targeted Therapies for Astrocytomas -- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer -- Future Treatments of Ependymoma -- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor -- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors -- Molecular Therapy for Neuroblastoma -- Ewing’s Sarcoma Family of Tumors: Molecular Targets Need Arrows -- Molecular Targeted Therapy for Wilms’ Tumor -- Molecular Therapy for Rhabdomyosarcoma -- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here? -- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology.
520 ## - SUMMARY, ETC.
Summary, etc Molecularly-Targeted Therapy for Childhood Cancer is a comprehensive exploration of the molecular aspects of childhood cancers that are currently being targeted therapeutically or are in the early phases of development. Each chapter describes key molecular characteristics of hematopoietic malignancies and solid tumors in children and young adults that are fundamental to the etiology, survival and drug resistance of these cancers as well as able to serve as tumor selective pathways for treatment. There has never been a more optimal time to explore the current and future use of molecularly targeted therapies in pediatric oncology. Conventional chemotherapeutic approaches have been dose intensified to such an extent that acute and late toxicities have reached maximal points while the rate of cure has slowed. The volume moves beyond conventional chemotherapeutic approaches to explore approaches that target tumor selective molecular and immunologic characteristics. The chapters further explore how such targeted therapies can begin to be integrated with conventional regimens in order to improve efficacy while reducing morbidity. While molecularly targeted therapies have generated great excitement in the world of oncology, their impact for pediatric patients may provide some of the greatest impact in part because of their developmental susceptibilities to conventional cytotoxic treatments. In addition, less toxic and more effective therapies hold great promise for improving the outcome of pediatric patients in developing countries where supportive care measures may not always be optimal. Molecularly-Targeted Therapy for Childhood Cancer is thus a timely first foray into the world of targeted, pathway directed treatment approaches for pediatric patients with cancer and brings us one step closer to the day when Paul Erhlich’s hope for therapeutic Magic Bullets becomes the conventional approach to cure.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Human genetics.
Topical term or geographic name as entry element Microbiology.
Topical term or geographic name as entry element Animal behavior.
Topical term or geographic name as entry element Cytology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Human Genetics.
Topical term or geographic name as entry element Molecular Medicine.
Topical term or geographic name as entry element Behavioural Sciences.
Topical term or geographic name as entry element Cell Biology.
Topical term or geographic name as entry element Medical Microbiology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Arceci, Robert J.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9780387690605
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-0-387-69062-9
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-03AUM Main Library2014-04-03 2014-04-03 E-Book   AUM Main Library614.5999