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Genetically Engineered Mice for Cancer Research (Record no. 17139)

000 -LEADER
fixed length control field 04912nam a22005175i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150232.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 111207s2012 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780387698052
978-0-387-69805-2
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC261-271
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
264 #1 -
-- New York, NY :
-- Springer New York,
-- 2012.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Green, Jeffrey E.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Genetically Engineered Mice for Cancer Research
Medium [electronic resource] :
Remainder of title design, analysis, pathways, validation and pre-clinical testing /
Statement of responsibility, etc edited by Jeffrey E. Green, Thomas Ried.
300 ## - PHYSICAL DESCRIPTION
Extent XX, 632 p.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Foreword -- Preface -- Overview of Designing Genetically-Engineered Mouse Models -- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer -- Using Recombineering Technology To Create Genetically Engineered Mouse Models -- Insertional Mutagenesis for Generating Mouse Models of Cancer -- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer -- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat -- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology -- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry -- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying Mammary Epithelial Stem and Progenitor Cells -- Differentiation Programs in Development and Cancer -- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse -- Mouse Models for Colorectal Cancer -- Src family tyrosine kinases: Implications for mammary tumor progression -- Maspin and Suppression of Tumor Metastasis -- Epigenetic Mouse Models -- Modeling Transforming Growth Factor-ß Signaling in Cancer -- Modeling Stromal-Epithelial Interactions.-  Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.-  Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models -- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models -- Animal Models for Breast Cancer Prevention Resarch -- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies -- Mouse Models in Preclinical Drug Development- Applications to CNS Models -- Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine -- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development -- Index.  .
520 ## - SUMMARY, ETC.
Summary, etc Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Human genetics.
Topical term or geographic name as entry element Medical laboratories.
Topical term or geographic name as entry element Microbiology.
Topical term or geographic name as entry element Medical parasitology.
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Human Genetics.
Topical term or geographic name as entry element Laboratory Medicine.
Topical term or geographic name as entry element Medical Microbiology.
Topical term or geographic name as entry element Animal Biochemistry.
Topical term or geographic name as entry element Parasitology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ried, Thomas.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9780387698038
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-0-387-69805-2
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-03AUM Main Library2014-04-03 2014-04-03 E-Book   AUM Main Library614.5999