//]]>

Acute Neuronal Injury (Record no. 17142)

000 -LEADER
fixed length control field 05035nam a22005055i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150232.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 110413s2010 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780387732268
978-0-387-73226-8
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC321-580
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.8
Edition number 23
264 #1 -
-- Boston, MA :
-- Springer US,
-- 2010.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Fujikawa, Denson G.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Acute Neuronal Injury
Medium [electronic resource] :
Remainder of title The Role of Excitotoxic Programmed Cell Death Mechanisms /
Statement of responsibility, etc edited by Denson G. Fujikawa.
300 ## - PHYSICAL DESCRIPTION
Extent XI, 306p. 176 illus., 16 illus. in color. With 16 page color insert.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Caspase-Independent Programmed Cell Death: General Considerations -- Caspase-Independent Cell Death Mechanisms in Simple Animal Models -- Programmed Necrosis: A “New” Cell Death Outcome for Injured Adult Neurons? -- Age-Dependence of Neuronal Apoptosis and of Caspase Activation -- Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms -- Focal Cerebral Ischemia -- Significant Role of Apoptosis-Inducing Factor (AIF) for Brain Damage Following Focal Cerebral Ischemia -- The Role of Poly(ADP-Ribose) Polymerase-1 (PARP-1) Activation in Focal Cerebral Ischemia -- Transient Global Ischemia -- Transient Global Cerebral Ischemia Produces Morphologically Necrotic, Not Apoptotic Neurons -- Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia -- Role of µ-Calpain I and Lysosomal Cathepsins in Hippocampal Neuronal Necrosis After Transient Global Ischemia in Primates -- Traumatic Central Nervous System (CNS) Injury -- Mitochondrial Damage in Traumatic CNS Injury -- Programmed Neuronal Cell Death Mechanisms in CNS Injury -- Hypoglycemic Neuronal Death -- Hypoglycemic Brain Damage -- Hypoglycemic Neuronal Death -- Seizure-Induced Neuronal Death -- Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death -- DNA Damage and Repair in the Brain: Implications for Seizure-Induced Neuronal Injury, Endangerment, and Neuroprotection -- Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis.
520 ## - SUMMARY, ETC.
Summary, etc This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal. Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists. About the Editor: Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism, and the Society for Neuroscience.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Neurology.
Topical term or geographic name as entry element Pathology.
Topical term or geographic name as entry element Psychiatry.
Topical term or geographic name as entry element Cytology.
Topical term or geographic name as entry element Neurobiology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Neurology.
Topical term or geographic name as entry element Pathology.
Topical term or geographic name as entry element Cell Biology.
Topical term or geographic name as entry element Neurobiology.
Topical term or geographic name as entry element Psychiatry.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9780387732251
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-0-387-73226-8
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-03AUM Main Library2014-04-03 2014-04-03 E-Book   AUM Main Library612.8
Languages: 
English |
العربية