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Multiscale Approaches to Protein Modeling (Record no. 17294)

000 -LEADER
fixed length control field 04384nam a22004455i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150234.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 101013s2011 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781441968890
978-1-4419-6889-0
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QD431-431.7
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 572.6
Edition number 23
264 #1 -
-- New York, NY :
-- Springer New York :
-- Imprint: Springer,
-- 2011.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Kolinski, Andrzej.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Multiscale Approaches to Protein Modeling
Medium [electronic resource] :
Remainder of title Structure Prediction, Dynamics, Thermodynamics and Macromolecular Assemblies /
Statement of responsibility, etc edited by Andrzej Kolinski.
250 ## - EDITION STATEMENT
Edition statement 1st.
300 ## - PHYSICAL DESCRIPTION
Extent XII, 355p. 80 illus., 16 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface -- Lattice polymers and protein models -- Multiscale approach to protein and peptide docking -- Coarse-grained models of proteins: theory and applications -- Coarse-grained modeling of biomolecules with transferable force field -- Effective all-atom potentials for protein studies -- Statistical contact potentials in protein coarse-grained modeling: From pair to multi-body potentials -- Bridging the atomic and coarse-grained descriptions of collective motions in proteins -- Structure-based models of biomolecules: stretching of proteins, dynamics of knots, hydrodynamic effects, and indentation of virus capsids -- Sampling protein energy landscapes –the quest for efficient algorithms -- Protein structure prediction: from recognition of matches with known structures to recombination of fragments -- Genome-wide protein structure prediction using template fragment reassembly -- Multiscale approach to protein folding dynamics -- Error estimation of template-based protein structure models -- Evaluation of protein structure prediction methods: issues and strategies -- Index.
520 ## - SUMMARY, ETC.
Summary, etc Multiscale Approaches to Protein Modeling is a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. The approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. Thanks to enormous progress in sequencing of genomic data, we presently know millions of protein sequences. At the same time, the number of experimentally solved protein structures is much smaller, ca. 60,000. This is because of the large cost of structure determination. Thus, theoretical, in silico, prediction of protein structures and dynamics is essential for understanding the molecular basis of drug action, metabolic and signaling pathways in living cells, designing new technologies in the life science and material sciences. Unfortunately, a “brute force” approach remains impractical. Folding of a typical protein (in vivo or in vitro) takes milliseconds to minutes, while state-of-the-art all-atom molecular mechanics simulations of protein systems can cover only a time period range of nanosecond to microseconds. This is the reason for the enormous progress in development of various mutiscale modeling techniques, applied to protein structure prediction, modeling of protein dynamics and folding pathways, in silico protein engineering, model-aided interpretation of experimental data, modeling of macromolecular assemblies and theoretical studies of protein thermodynamics. Coarse-graining of the proteins’ conformational space is a common feature of all these approaches, although the details and the underlying physical models span a very broad spectrum.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Life sciences.
Topical term or geographic name as entry element Bioinformatics.
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Life Sciences.
Topical term or geographic name as entry element Protein Science.
Topical term or geographic name as entry element Protein Structure.
Topical term or geographic name as entry element Bioinformatics.
Topical term or geographic name as entry element Computational Biology/Bioinformatics.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9781441968883
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-4419-6889-0
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-04AUM Main Library2014-04-04 2014-04-04 E-Book   AUM Main Library572.6