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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20140310150234.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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110301s2011 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781441969569 |
|
978-1-4419-6956-9 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QH301-705 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
570 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
New York, NY : |
| -- |
Springer New York, |
| -- |
2011. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Booß-Bavnbek, Bernhelm. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
BetaSys |
| Medium |
[electronic resource] : |
| Remainder of title |
Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells / |
| Statement of responsibility, etc |
edited by Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström. |
| 250 ## - EDITION STATEMENT |
|---|
| Edition statement |
1. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XX, 556 p. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Systems Biology ; |
| Volume number/sequential designation |
2 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Preface -- Systems biology of β-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in β-cells -- β-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic β-cells -- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in β-cell function -- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the β-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in β-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Life sciences. |
|
|---|
| Topical term or geographic name as entry element |
Human genetics. |
|
|---|
| Topical term or geographic name as entry element |
Diabetes. |
|
|---|
| Topical term or geographic name as entry element |
Bioinformatics. |
|
|---|
| Topical term or geographic name as entry element |
Biological models. |
|
|---|
| Topical term or geographic name as entry element |
Life Sciences. |
|
|---|
| Topical term or geographic name as entry element |
Systems Biology. |
|
|---|
| Topical term or geographic name as entry element |
Human Genetics. |
|
|---|
| Topical term or geographic name as entry element |
Bioinformatics. |
|
|---|
| Topical term or geographic name as entry element |
Diabetes. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Klösgen, Beate. |
| Relator term |
editor. |
|
|---|
| Personal name |
Larsen, Jesper. |
| Relator term |
editor. |
|
|---|
| Personal name |
Pociot, Flemming. |
| Relator term |
editor. |
|
|---|
| Personal name |
Renström, Erik. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9781441969552 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4419-6956-9 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
