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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20140310150235.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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120905s2013 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781441999672 |
|
978-1-4419-9967-2 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RC261-271 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
614.5999 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
New York, NY : |
| -- |
Springer New York : |
| -- |
Imprint: Springer, |
| -- |
2013. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Karpf, Adam R. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Epigenetic Alterations in Oncogenesis |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Adam R. Karpf. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XV, 348 p. 22 illus. in color. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Advances in Experimental Medicine and Biology, |
| International Standard Serial Number |
0065-2598 ; |
| Volume number/sequential designation |
754 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Preface -- Section I: Epigenetic Marks and Mechanisms -- DNA methyltransferases (DNMTs), DNA damage repair, and cancer -- DNA hypomethylation and hemimethylation in cancer -- Ten Eleven Translocation (TET) Enzymes and 5-hydroxymethylation in Mammalian Development and Cancer -- Altered histone modifications in cancer -- Nucleosome occupancy and gene regulation during tumorigenesis -- Section II: The Impact of Epigenetic Alterations on Cancer Biology -- Epigenetic regulation of miRNAs in cancer -- DNA hypomethylation and activation of germline-specific genes in cancer -- APC and DNA demethylation in cell fate specification and intestinal cancer -- Epigenetic changes during cell transformation -- Epigenetic reprogramming of mesenchymal stem cells -- Section III: Clinical Implications and Analysis Methods -- Environmental toxicants, epigenetics, and cancer -- Blood derived DNA methylation markers of cancer risk -- Epigenetic therapies in MDS and AML -- Epigenetic targeting therapies to overcome chemotherapy resistance -- Methods for cancer epigenome analysis -- Index. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Oncology. |
|
|---|
| Topical term or geographic name as entry element |
Human genetics. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Cancer Research. |
|
|---|
| Topical term or geographic name as entry element |
Human Genetics. |
|
|---|
| Topical term or geographic name as entry element |
Oncology. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9781441999665 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4419-9967-2 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
