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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants (Record no. 17465)

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fixed length control field 04334nam a22004695i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150236.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
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fixed length control field 111205s2012 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781461415428
978-1-4614-1542-8
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC321-580
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.8
Edition number 23
264 #1 -
-- Boston, MA :
-- Springer US,
-- 2012.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Antkiewicz-Michaluk, Lucyna.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants
Medium [electronic resource] :
Remainder of title New Vistas In Parkinson's Disease Therapy /
Statement of responsibility, etc edited by Lucyna Antkiewicz-Michaluk, Hans Rommelspacher.
250 ## - EDITION STATEMENT
Edition statement 1.
300 ## - PHYSICAL DESCRIPTION
Extent X, 178 p.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Current Topics in Neurotoxicity ;
Volume number/sequential designation 1
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Two faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endogenous neurotoxin or a neuromodulator? -- Isoquinolines as a neurotoxins: action and molecular mechanism -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline – a potent neuroprotecting agent -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies -- Beta-carbolines as neurotoxins -- Neuroprotective β-carbolines: occurrence, formation and biodegradation -- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase -- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria -- Antioxidant properties of β-carbolines -- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies -- Prospects for new treatment options in neurodegenerative diseases.
520 ## - SUMMARY, ETC.
Summary, etc This book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.  Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease. The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson's Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson's disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): BCs and TIQs. These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Neurochemistry.
Topical term or geographic name as entry element Pharmacy.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Neurochemistry.
Topical term or geographic name as entry element Pharmacy.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Rommelspacher, Hans.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9781461415411
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-4614-1542-8
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-04AUM Main Library2014-04-04 2014-04-04 E-Book   AUM Main Library612.8