| 000 -LEADER |
|---|
| fixed length control field |
04194nam a22004815i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140310150236.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
120613s2012 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781461433453 |
|
978-1-4614-3345-3 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QR46 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.9041 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
New York, NY : |
| -- |
Springer New York : |
| -- |
Imprint: Springer, |
| -- |
2012. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Minarovits, Janos. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Patho-Epigenetics of Disease |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Janos Minarovits, Hans Helmut Niller. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIII, 465 p. 25 illus., 14 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Epigenetic regulatory mechanisms -- Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome -- Dysfunction of the Methyl-Cpg Binding Protein Mecp2 in Rett Syndrome -- Epigenetic Alterations in Glioblastoma Multiforme -- Aberrant Epigenetic Regulation in Breast Cancer -- The Impact of Epigenetic Alterations on Diagnosis, Prediction and Therapy of Prostate Cancer -- Epigenetic Reprogramming in Lung Carcinomas -- Epigenetic changes in virus associated neoplasms -- Genetic and Epigenetic Determinants of Aggression -- Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder -- Disruption of Epigenetic Mechanisms in Autoimmune Syndromes -- Imprinting Disorders -- Epigenetics of cardiovascular diseases -- Microbe-induced epigenetic alterations. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Immunology. |
|
|---|
| Topical term or geographic name as entry element |
Microbiology. |
|
|---|
| Topical term or geographic name as entry element |
Medical virology. |
|
|---|
| Topical term or geographic name as entry element |
Emerging infectious diseases. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Medical Microbiology. |
|
|---|
| Topical term or geographic name as entry element |
Medicine/Public Health, general. |
|
|---|
| Topical term or geographic name as entry element |
Virology. |
|
|---|
| Topical term or geographic name as entry element |
Infectious Diseases. |
|
|---|
| Topical term or geographic name as entry element |
Immunology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Niller, Hans Helmut. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9781461433446 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4614-3345-3 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
