000 -LEADER |
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03911nam a22004695i 4500 |
003 - CONTROL NUMBER IDENTIFIER |
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OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20140310150236.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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120622s2012 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781461435730 |
|
978-1-4614-3573-0 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
RB155-155.8 |
|
Classification number |
QH431 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
611.01816 |
Edition number |
23 |
|
Classification number |
599.935 |
Edition number |
23 |
264 #1 - |
-- |
New York, NY : |
-- |
Springer New York : |
-- |
Imprint: Springer, |
-- |
2012. |
912 ## - |
-- |
ZDB-2-SBL |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Kadenbach, Bernhard. |
Relator term |
editor. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
Mitochondrial Oxidative Phosphorylation |
Medium |
[electronic resource] : |
Remainder of title |
Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology / |
Statement of responsibility, etc |
edited by Bernhard Kadenbach. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
XI, 372 p. 33 illus., 26 illus. in color. |
Other physical details |
online resource. |
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
Advances in Experimental Medicine and Biology, |
International Standard Serial Number |
0065-2598 ; |
Volume number/sequential designation |
748 |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Preface -- Introduction -- Mitochondrial Dynamics: The Intersection of Form and Function -- Biogenesis of Mitochondrial Proteins -- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology -- Supramolecular Organization of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation -- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain -- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins -- Evolution of the Couple Cytochrome C and Cytochrome C Oxidase in Primates -- Reaction Mechanism of Mammalian Mitochondrial Cytochrome C Oxidase -- Phosphorylation of Mammalian Cytochrome C and Cytochrome C Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease -- Individual Biochemical Behavior Versus Biological Robustness: Spotlight on the Regulation of Cytochrome C Oxidase -- Bigenomic Regulation of Cytochrome C Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism -- Cytochrome C Oxidase and its Role in Neurodegeneration and Neuroprotection -- The Many Clinical Faces of Cytochrome C Oxidase Deficiency -- Index. |
520 ## - SUMMARY, ETC. |
Summary, etc |
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Medicine. |
|
Topical term or geographic name as entry element |
Human genetics. |
|
Topical term or geographic name as entry element |
Gene expression. |
|
Topical term or geographic name as entry element |
Cytology. |
|
Topical term or geographic name as entry element |
Biomedicine. |
|
Topical term or geographic name as entry element |
Human Genetics. |
|
Topical term or geographic name as entry element |
Gene Expression. |
|
Topical term or geographic name as entry element |
Cell Biology. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9781461435723 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4614-3573-0 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |