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p53 in the Clinics (Record no. 17514)

000 -LEADER
fixed length control field 03272nam a22004335i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150236.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120829s2013 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781461436768
978-1-4614-3676-8
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC261-271
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
264 #1 -
-- New York, NY :
-- Springer New York :
-- Imprint: Springer,
-- 2013.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Hainaut, Pierre.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title p53 in the Clinics
Medium [electronic resource] /
Statement of responsibility, etc edited by Pierre Hainaut, Magali Olivier, Klas G. Wiman.
300 ## - PHYSICAL DESCRIPTION
Extent X, 355 p. 45 illus., 30 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Foreword -- p53 activities and the hallmarks of cancer -- The inheritance of p53 -- p53: Guardian of the metabolome -- The p53 family and stem cell biology -- Mutant p53-driven tumorigenesis -- Humanized p53 mouse models -- p53 models for mammary carcinogenesis -- TP53 somatic mutations: Prognostic and predictive value in human cancers -- Assessing TP53 status in human tumors - lessons from breast cancer -- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome -- TP53 gene therapy -- Upstream targets in the p53 pathway -- p53-reactivating molecules as research tools and anti-cancer drugs -- Restoring mutant p53 activity -- p53-immunotherapy of cancer -- Designing p53 trials: a surgical oncologist view -- p53 in the clinic: a pathologist view -- p53 in genetic counseling -- Index.
520 ## - SUMMARY, ETC.
Summary, etc With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of  25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Toxicology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Pharmacology/Toxicology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Olivier, Magali.
Relator term editor.
Personal name Wiman, Klas G.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9781461436751
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-4614-3676-8
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-04AUM Main Library2014-04-04 2014-04-04 E-Book   AUM Main Library614.5999

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