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Complement Therapeutics (Record no. 17542)

000 -LEADER
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003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150237.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120919s2013 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781461441182
978-1-4614-4118-2
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QR180-189.5
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 616.079
Edition number 23
264 #1 -
-- Boston, MA :
-- Springer US :
-- Imprint: Springer,
-- 2013.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Lambris, John D.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Complement Therapeutics
Medium [electronic resource] /
Statement of responsibility, etc edited by John D. Lambris, V. Michael Holers, Daniel Ricklin.
300 ## - PHYSICAL DESCRIPTION
Extent VIII, 320 p. 89 illus., 62 illus. in color.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Advances in Experimental Medicine and Biology,
International Standard Serial Number 0065-2598 ;
Volume number/sequential designation 734
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Progress and Trends in Complement Therapeutics -- Inhibition of the serine proteases of the complement system -- The role of MASP-1/3 in complement activation -- Membrane-bound complement regulatory proteins as biomarkers and potential therapeutic targets for SLE -- DAF as a therapeutic target for steroid hormones: implications for host pathogen interactions -- Targeting gC1qR domains for therapy against infection and inflammation -- The Alternative C5a Receptor Function -- The effects of selective complement- and CD14-inhibition on the E. coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and tissue factor functional activity in human whole blood -- CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation -- Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anti-complement strategies -- Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for new Therapeutic Approaches -- C3 Glomerulonephritis/CFHR5 Nephropathy is an endemic disease in Cyprus: Clinical and molecular findings in 21 families -- Complement-targeted therapeutics in periodontitis -- Complement system activation in cardiac and skeletal muscle pathology: Friend or foe? -- Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells -- Complement-mediated microvascular injury leads to chronic rejection -- Targeting complement at the time of transplantation -- Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines -- Non-invasive detection of complement activation through radiologic imaging -- Highly Multiplexed Proteomic Platform for Biomarker Discovery, Diagnostics and Therapeutics -- Complement in Action: A Review of Patent Trends From 1976 through 2011.
520 ## - SUMMARY, ETC.
Summary, etc This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials.   The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Immunology.
Topical term or geographic name as entry element Emerging infectious diseases.
Topical term or geographic name as entry element Pathology.
Topical term or geographic name as entry element Microbiology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Immunology.
Topical term or geographic name as entry element Microbiology.
Topical term or geographic name as entry element Infectious Diseases.
Topical term or geographic name as entry element Pathology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Holers, V. Michael.
Relator term editor.
Personal name Ricklin, Daniel.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9781461441175
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-4614-4118-2
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-04AUM Main Library2014-04-04 2014-04-04 E-Book   AUM Main Library616.079
Languages: 
English |
العربية