000 -LEADER |
fixed length control field |
03168nam a22004455i 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20140310150238.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
fixed length control field |
cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
130321s2013 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781461462804 |
|
978-1-4614-6280-4 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
RB155-155.8 |
|
Classification number |
QH431 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
611.01816 |
Edition number |
23 |
|
Classification number |
599.935 |
Edition number |
23 |
264 #1 - |
-- |
New York, NY : |
-- |
Springer New York : |
-- |
Imprint: Springer, |
-- |
2013. |
912 ## - |
-- |
ZDB-2-SBL |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Mittelman, David. |
Relator term |
editor. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
Stress-Induced Mutagenesis |
Medium |
[electronic resource] / |
Statement of responsibility, etc |
edited by David Mittelman. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
XV, 275 p. 48 illus., 31 illus. in color. |
Other physical details |
online resource. |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Preface -- Stress-induced mutagenesis in bacteria -- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress -- Transcription-mediated mutagenic processes -- Transposon mutagenesis in disease, drug discovery and bacterial evolution -- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution -- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors -- Microsatellite Repeats: Canaries in the Coalmine -- Genetic instability Induced by hypoxic stress -- Radiation-induced delayed genome Instability and hypermutation in mammalian cells -- Radiation-induced bystander effects and stress-induced mutagenesis -- Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis -- The transgenerational effects of parental exposure to mutagens in mammals -- Revisiting mutagenesis in the age of high-throughput sequencing -- Index. |
520 ## - SUMMARY, ETC. |
Summary, etc |
The discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In “Stress-Induced Mutagenesis”, leading experts provide the key evidence for and the molecular details of stress-induced genetic and epigenetic mutation, integrating cross-disciplinary observations from a number of species and biological systems, including human. The observations have vast implications for evolutionary biology but also for human medicine. A comprehensive understanding of stress-induced mutagenesis and the processes underlying evolvability, will enable gains in the treatment and management of cancer, as well as other human disorders that result from damaged or unstable genomes. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Medicine. |
|
Topical term or geographic name as entry element |
Human genetics. |
|
Topical term or geographic name as entry element |
Biochemistry. |
|
Topical term or geographic name as entry element |
Biomedicine. |
|
Topical term or geographic name as entry element |
Human Genetics. |
|
Topical term or geographic name as entry element |
Biochemistry, general. |
|
Topical term or geographic name as entry element |
Biomedicine general. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9781461462798 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4614-6280-4 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |