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Pharmacoresistance in Epilepsy (Record no. 17642)

000 -LEADER
fixed length control field 04527nam a22004455i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150238.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130507s2013 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781461464648
978-1-4614-6464-8
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC321-580
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.8
Edition number 23
264 #1 -
-- New York, NY :
-- Springer New York :
-- Imprint: Springer,
-- 2013.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Rocha, Luisa.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Pharmacoresistance in Epilepsy
Medium [electronic resource] :
Remainder of title From Genes and Molecules to Promising Therapies /
Statement of responsibility, etc edited by Luisa Rocha, Esper A. Cavalheiro.
300 ## - PHYSICAL DESCRIPTION
Extent XII, 329 p. 40 illus., 26 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Pharmacoresistance and Epilepsy -- Genes involved in pharmacoresistant epilepsy -- Pathological oscillations in the pharmacoresistant epileptic brain -- Molecular mechanisms of pharmacoresistant epilepsy -- Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance -- Intracellular pathways associated with neuronal survival and death in epilepsy -- The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration -- Proteomics-based strategy to identify biomarkers and pharmacological targets in temporal lobe epilepsy -- Abnormalities of GABA system and human pharmacoresistant epilepsy -- Pharmacoresistant epilepsy and immune system -- Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy -- Experimental models to study pharmacoresistance in epilepsy -- Resistance to epileptogenesis in the Neotropical rodent Proechimys -- On the development of new antiepileptic drugs for the treatment of pharmacoresistant epilepsy – Different approaches to different hypothesis -- Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy -- Vagus Nerve Stimulation for Intractable Seizures -- The role of neuromodulation in the treatment of refractory epilepsy -- Transcranial magnetic stimulation and refractory partial epilepsy -- Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity -- Physical exercise as a strategy to reduce seizure susceptibility.
520 ## - SUMMARY, ETC.
Summary, etc Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Toxicology.
Topical term or geographic name as entry element Neurology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Neurology.
Topical term or geographic name as entry element Pharmacology/Toxicology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Cavalheiro, Esper A.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9781461464631
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-4614-6464-8
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-05AUM Main Library2014-04-05 2014-04-05 E-Book   AUM Main Library612.8