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005 - DATE AND TIME OF LATEST TRANSACTION |
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20140310150238.0 |
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131008s2013 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781461482895 |
|
978-1-4614-8289-5 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
RB155-155.8 |
|
Classification number |
QH431 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
611.01816 |
Edition number |
23 |
264 #1 - |
-- |
New York, NY : |
-- |
Springer New York : |
-- |
Imprint: Springer, |
-- |
2013. |
912 ## - |
-- |
ZDB-2-SBL |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Liebermann, Dan A. |
Relator term |
editor. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
Gadd45 Stress Sensor Genes |
Medium |
[electronic resource] / |
Statement of responsibility, etc |
edited by Dan A. Liebermann, Barbara Hoffman. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
X, 134 p. 18 illus., 11 illus. in color. |
Other physical details |
online resource. |
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
Advances in Experimental Medicine and Biology, |
International Standard Serial Number |
0065-2598 ; |
Volume number/sequential designation |
793 |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver — Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index. |
520 ## - SUMMARY, ETC. |
Summary, etc |
Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Medicine. |
|
Topical term or geographic name as entry element |
Human genetics. |
|
Topical term or geographic name as entry element |
Medical genetics. |
|
Topical term or geographic name as entry element |
Biochemistry. |
|
Topical term or geographic name as entry element |
Biomedicine. |
|
Topical term or geographic name as entry element |
Gene Function. |
|
Topical term or geographic name as entry element |
Biochemistry, general. |
|
Topical term or geographic name as entry element |
Human Genetics. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Hoffman, Barbara. |
Relator term |
editor. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9781461482888 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4614-8289-5 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |