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003 - CONTROL NUMBER IDENTIFIER |
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005 - DATE AND TIME OF LATEST TRANSACTION |
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20140310150239.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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100301s2010 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781607614951 |
|
978-1-60761-495-1 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
RM1-950 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
615 |
Edition number |
23 |
264 #1 - |
-- |
Totowa, NJ : |
-- |
Humana Press, |
-- |
2010. |
912 ## - |
-- |
ZDB-2-SBL |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Mattson, Mark P. |
Relator term |
editor. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
Hormesis |
Medium |
[electronic resource] : |
Remainder of title |
A Revolution in Biology, Toxicology and Medicine / |
Statement of responsibility, etc |
edited by Mark P. Mattson, Edward J. Calabrese. |
300 ## - PHYSICAL DESCRIPTION |
Other physical details |
online resource. |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Hormesis: What it is and Why it Matters -- Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response -- The Fundamental Role of Hormesis in Evolution -- Transcriptional Mediators of Cellular Hormesis -- The Devil is in the Dose: Complexity of Receptor Systems and Responses -- Exercise-Induced Hormesis -- Dietary Energy Intake, Hormesis, and Health -- Couch Potato: The Antithesis of Hormesis -- Hormesis and Aging -- The Hormetic Pharmacy: The Future of Natural Products and Man-Made Drugs in Disease Prevention and Treatment. |
520 ## - SUMMARY, ETC. |
Summary, etc |
Hormesis is defined as any circumstance in which exposure of a cell or organism to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book "Hormesis: A Revolution in Biology, Toxicology and Medicine" describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular underpinnings of the biphasic dose response/hormesis. The implications of the tapping of cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described. From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cardiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book. Features Groundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth. Explains why the principle of hormesis is important to our health, our environment, and the future of our planet. Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety. Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems. Illustrates how disorders such as diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses. Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Medicine. |
|
Topical term or geographic name as entry element |
Human physiology. |
|
Topical term or geographic name as entry element |
Neurosciences. |
|
Topical term or geographic name as entry element |
Toxicology. |
|
Topical term or geographic name as entry element |
Biomedicine. |
|
Topical term or geographic name as entry element |
Pharmacology/Toxicology. |
|
Topical term or geographic name as entry element |
Neurosciences. |
|
Topical term or geographic name as entry element |
Molecular Medicine. |
|
Topical term or geographic name as entry element |
Human Physiology. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Calabrese, Edward J. |
Relator term |
editor. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9781607614944 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-60761-495-1 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |