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03391nam a22004335i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20140310150239.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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130419s2013 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781627034203 |
|
978-1-62703-420-3 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QH345 |
|
|---|
| Classification number |
QD415-436 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
572 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Totowa, NJ : |
| -- |
Humana Press : |
| -- |
Imprint: Humana Press, |
| -- |
2013. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Youssef, Jihan A. |
| Relator term |
author. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Peroxisome Proliferator-Activated Receptors |
| Medium |
[electronic resource] : |
| Remainder of title |
Discovery and Recent Advances / |
| Statement of responsibility, etc |
by Jihan A. Youssef, Mostafa Z. Badr. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
IX, 137 p. 14 illus., 5 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Introduction.- History of PPAR Discovery: Peroxisomes -- Peroxisomal biogenesis and diseases -- Peroxisome proliferation.- Peroxisome Proliferator-Activated Receptors: Chromosomal location and gene polymorphism -- Protein structure -- PPAR Ligands: Endogenous ligands -- Exogenous PPAR modulators -- Tissue Distribution and Versatile Functions of PPARs: Neurological functions of PPARs.- PPARs and the cardiovascular system.- PPARs in pulmonary physiology and disease.- Gastrointestinal roles of PPARs.- PPAR functions in the liver.- Roles of PPARs in the pancreas.- PPARs in the urinary tract physiology and pathophysiology.- PPARs in the reproductive system -- Bone metabolism and PPARs.- Roles of PPARs in skeletal muscle biology.- Skin PPARs.- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions: Posttranslational control of PPARs.- Mechanism of action.- Animal Models in PPAR Research.- Safety of PPAR Agonists.- The Future of PPAR Research. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described. As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Life sciences. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry. |
|
|---|
| Topical term or geographic name as entry element |
Cell receptors. |
|
|---|
| Topical term or geographic name as entry element |
Life Sciences. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry, general. |
|
|---|
| Topical term or geographic name as entry element |
Receptors. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Badr, Mostafa Z. |
| Relator term |
author. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9781627034197 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-62703-420-3 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
