| 000 -LEADER |
|---|
| fixed length control field |
03818nam a22005055i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140310150239.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
101109s2011 sz | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783034602778 |
|
978-3-0346-0277-8 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QR46 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.9041 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Basel : |
| -- |
Springer Basel, |
| -- |
2011. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dormitzer, Philip R. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Replicating Vaccines |
| Medium |
[electronic resource] : |
| Remainder of title |
A New Generation / |
| Statement of responsibility, etc |
edited by Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli. |
| 250 ## - EDITION STATEMENT |
|---|
| Edition statement |
First. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIII, 447 p. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Birkhäuser Advances in Infectious Diseases |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
SECTION 1: Today’s Live Attenuated Vaccines -- Live Vaccines and their Role in Modern Vaccinology -- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster -- Classical Live Viral Vaccines -- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines -- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus -- Live Attenuated Shigella Vaccines. Is encouraging good enough? -- New generation BCG vaccines -- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines -- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines -- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches -- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread -- RSV Deletion Mutant – Innate Immunity -- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity -- SECTION 4: New Types of Replicating Vaccines -- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors -- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines -- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines -- Alphavirus Particle-based Vaccine Vectors -- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Immunology. |
|
|---|
| Topical term or geographic name as entry element |
Microbiology. |
|
|---|
| Topical term or geographic name as entry element |
Vaccines. |
|
|---|
| Topical term or geographic name as entry element |
Medical virology. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Medical Microbiology. |
|
|---|
| Topical term or geographic name as entry element |
Vaccine. |
|
|---|
| Topical term or geographic name as entry element |
Immunology. |
|
|---|
| Topical term or geographic name as entry element |
Virology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mandl, Christian W. |
| Relator term |
editor. |
|
|---|
| Personal name |
Rappuoli, Rino. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783034602761 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-0346-0277-8 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
