000 -LEADER |
fixed length control field |
03284nam a22004815i 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20140310150240.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
fixed length control field |
cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
100301s2010 gw | s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9783642031038 |
|
978-3-642-03103-8 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
QH345 |
|
Classification number |
QD415-436 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
572 |
Edition number |
23 |
264 #1 - |
-- |
Berlin, Heidelberg : |
-- |
Springer Berlin Heidelberg, |
-- |
2010. |
912 ## - |
-- |
ZDB-2-SBL |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Rhoads, Robert E. |
Relator term |
editor. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
miRNA Regulation of the Translational Machinery |
Medium |
[electronic resource] / |
Statement of responsibility, etc |
edited by Robert E. Rhoads. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
X, 115p. 23 illus., 4 illus. in color. |
Other physical details |
online resource. |
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
Progress in Molecular and Subcellular Biology, |
International Standard Serial Number |
0079-6484 ; |
Volume number/sequential designation |
50 |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression -- Translational Control of Endogenous MicroRNA Target Genes in -- Translational Inhibition by MicroRNAs in Plants -- Regulation of p27 mRNA Expression by MicroRNAs -- The Inhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs -- MicroRNA-Mediated mRNA Deadenylation and Repression of Protein Synthesis in a Mammalian Cell-Free System -- miRNA Effects on mRNA Closed-Loop Formation During Translation Initiation. |
520 ## - SUMMARY, ETC. |
Summary, etc |
The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1). |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Life sciences. |
|
Topical term or geographic name as entry element |
Gene expression. |
|
Topical term or geographic name as entry element |
Medicine. |
|
Topical term or geographic name as entry element |
Biochemistry. |
|
Topical term or geographic name as entry element |
Cytology. |
|
Topical term or geographic name as entry element |
Life Sciences. |
|
Topical term or geographic name as entry element |
Biochemistry, general. |
|
Topical term or geographic name as entry element |
Cell Biology. |
|
Topical term or geographic name as entry element |
Gene Expression. |
|
Topical term or geographic name as entry element |
Molecular Medicine. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9783642031021 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-03103-8 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |