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Diabetes, Insulin and Alzheimer's Disease (Record no. 17901)

000 -LEADER
fixed length control field 04313nam a22004575i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150240.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 100316s2010 gw | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783642043000
978-3-642-04300-0
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC321-580
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.8
Edition number 23
264 #1 -
-- Berlin, Heidelberg :
-- Springer Berlin Heidelberg,
-- 2010.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Craft, Suzanne.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Diabetes, Insulin and Alzheimer's Disease
Medium [electronic resource] /
Statement of responsibility, etc edited by Suzanne Craft, Yves Christen.
300 ## - PHYSICAL DESCRIPTION
Extent XIII, 250p. 30 illus., 21 illus. in color.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Research and Perspectives in Alzheimer's Disease,
International Standard Serial Number 0945-6066
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Insulin Action in the Brain and the Pathogenesis of Alzheimer’s Disease -- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies -- Insulin-Mediated Neuroplasticity in the Central Nervous System -- Stress Hormones and Neuroplasticity in the Diabetic Brain -- Diabetes and the Brain – An Epidemiologic Perspective -- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors -- The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer’s Disease: An Epidemiological Perspective -- The Role of Insulin Dysregulation in Aging and Alzheimer’s Disease -- Is Alzheimer’s a Disorder of Ageing and Why Don’t Mice get it? The Centrality of Insulin Signalling to Alzheimer’s Disease Pathology -- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD -- Diet, Abeta Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimer’s Disease -- Serum IGF-I, Life Style, and Risk of Alzheimer’s disease.
520 ## - SUMMARY, ETC.
Summary, etc Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet’s evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin’s involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer’s disease. This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Geriatrics.
Topical term or geographic name as entry element Endocrinology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Endocrinology.
Topical term or geographic name as entry element Geriatrics/Gerontology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Christen, Yves.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783642042997
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-3-642-04300-0
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-05AUM Main Library2014-04-05 2014-04-05 E-Book   AUM Main Library612.8
Languages: 
English |
العربية