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| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310150241.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
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100721s2010 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783642121760 |
|
978-3-642-12176-0 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QK861-899 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
572.572 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Berlin, Heidelberg : |
| -- |
Springer Berlin Heidelberg : |
| -- |
Imprint: Springer, |
| -- |
2010. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lord, J. Michael. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Toxic Plant Proteins |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by J. Michael Lord, Martin R. Hartley. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
X, 270p. 41 illus., 12 illus. in color. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Plant Cell Monographs, |
| International Standard Serial Number |
1861-1370 ; |
| Volume number/sequential designation |
18 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Evolution of Plant Ribosome-Inactivating Proteins -- RNA N-Glycosidase Activity of Ribosome-Inactivating Proteins -- Enzymatic Activities of Ribosome-Inactivating Proteins -- Type I Ribosome-Inactivating Proteins from Saponaria officinalis -- Type 1 Ribosome-Inactivating Proteins from the Ombú Tree (Phytolacca dioica L.) -- Sambucus Ribosome-Inactivating Proteins and Lectins -- Ribosome-Inactivating Proteins from Abrus pulchellus -- Ribosome-Inactivating Proteins in Cereals -- Ribosome Inactivating Proteins and Apoptosis -- The Synthesis of Ricinus communis Lectins -- How Ricin Reaches its Target in the Cytosol of Mammalian Cells -- Ribosome-Inactivating Protein-Containing Conjugates for Therapeutic Use. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Many plants produce enzymes collectively known as ribosome-inactivating proteins (RIPs). RIPs catalyze the removal of an adenine residue from a conserved loop in the large ribosomal RNA. The adenine residue removed by this depurination is crucial for the binding of elongation factors. Ribosomes modified in this way are no longer able to carry out protein synthesis. Most RIPs exist as single polypeptides (Type 1 RIPs) which are largely non-toxic to mammalian cells because they are unable to enter them and thus cannot reach their ribosomal substrate. In some instances, however, the RIP forms part of a heterodimer where its partner polypeptide is a lectin (Type 2 RIPs). These heterodimeric RIPs are able to bind to and enter mammalian cells. Their ability to reach and modify ribosomes in target cells means these proteins are some of the most potently cytotoxic poisons found in nature, and are widely assumed to play a protective role as part of the host plant’s defenses. RIPs are able to further damage target cells by inducing apoptosis. In addition, certain plants produce lectins lacking an RIP component but which are also cytotoxic. This book focuses on the structure/function and some potential applications of these toxic plant proteins. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Life sciences. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry. |
|
|---|
| Topical term or geographic name as entry element |
Cytology. |
|
|---|
| Topical term or geographic name as entry element |
Botany. |
|
|---|
| Topical term or geographic name as entry element |
Plant physiology. |
|
|---|
| Topical term or geographic name as entry element |
Life Sciences. |
|
|---|
| Topical term or geographic name as entry element |
Plant Biochemistry. |
|
|---|
| Topical term or geographic name as entry element |
Cell Biology. |
|
|---|
| Topical term or geographic name as entry element |
Plant Physiology. |
|
|---|
| Topical term or geographic name as entry element |
Plant Sciences. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hartley, Martin R. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783642121753 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-12176-0 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
