| 000 -LEADER |
|---|
| fixed length control field |
03027nam a22004455i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140310150241.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100929s2010 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783642133299 |
|
978-3-642-13329-9 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RC261-271 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
614.5999 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Berlin, Heidelberg : |
| -- |
Springer Berlin Heidelberg : |
| -- |
Imprint: Springer, |
| -- |
2010. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Simon, M. Celeste. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Diverse Effects of Hypoxia on Tumor Progression |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by M. Celeste Simon. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
X, 146 p. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Current Topics in Microbiology and Immunology, |
| International Standard Serial Number |
0070-217X ; |
| Volume number/sequential designation |
345 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
The HIF-2?-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization -- Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance -- Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression -- The Role of Hypoxia Regulated microRNAs in Cancer -- Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration -- Hypoxia-Inducible Factors as Essential Regulators of Inflammation -- Hypoxia and Metastasis in Breast Cancer. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Oncology. |
|
|---|
| Topical term or geographic name as entry element |
Human physiology. |
|
|---|
| Topical term or geographic name as entry element |
Embryology. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Cancer Research. |
|
|---|
| Topical term or geographic name as entry element |
Embryology. |
|
|---|
| Topical term or geographic name as entry element |
Human Physiology. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783642133282 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-13329-9 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
