| 000 -LEADER |
|---|
| fixed length control field |
03862nam a22004095i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140310150241.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100917s2010 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783642135170 |
|
978-3-642-13517-0 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
R-RZ |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
610 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Berlin, Heidelberg : |
| -- |
Springer Berlin Heidelberg : |
| -- |
Imprint: Springer, |
| -- |
2010. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Christen, Yves. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Novel Insights into Adipose Cell Functions |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Yves Christen, Karine Clément, Bruce M. Spiegelman. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
X, 160p. 34 illus., 18 illus. in color. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Research and Perspectives in Endocrine Interactions, |
| International Standard Serial Number |
1861-2253 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Pathological Alteration of Human Adipose Tissue in Obesity -- Dynamics of Human Adipose Tissue. Regulatory Mechanisms and Consequences for Fat Cells and the Whole Body -- Metabolism of Fatty Acids in Adipocytes -- The Role of Hypoxia in Adipocyte Function and Dysfunction -- Brown Adipose Tissue In Humans: A New Target for Anti-Obesity Therapy -- Adipose Tissue Dysfunction: A Multistep Process -- Fat Cell Progenitors: Origins and Plasticity -- Transcriptional Regulation of Brown and White Adipogenesis -- Transcriptional Control of Gene Expression in Different Adipose Tissue Depots -- Epigenetic Approaches to Adipose Biology -- Metabolic and Angiogenic Consequences of the Presence or Absence of UCP1 -- Metabolic Responses to Weight Perturbation -- Understanding Causal Relationships in the Metabolic Syndrome: Recent Insights from Extreme Human Phenotypes. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Obesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders. Environmental, behavioural, genetic, epigenetic and multiple biological factors interact to cause obesity. In this context adipose tissue depots have been under focus in the last decades and pivotal concepts have emerged from the studies of their complex biology. While the white adipose tissue (WAT) is the main energy repository in the body (mobilizing fatty acids according to body needs) thanks to white adipocyte properties, WAT is also a multicellular organ communicating with other body organs (brain, muscles, liver, pancreas, heart, vessels, etc…) via complex networks of endocrine signals. The discovery of leptin in 1994 led to recognize WAT as a master organ at the crossroad of a myriad of physiological interactions to control food intake, energy balance, glucose and lipid metabolism, immunity and reproduction. The phenotype, amount and biology of each WAT component are profoundly altered in human obesity. Adipose plasticity also accounts for the extraordinary capacity of adipose precursors to differentiate into functional cardiomyocytes, osteoblasts, haematopoietic and neural cells, a convenient property for regenerative medicine. Finally, while initially thought to exert a negligible role in humans, the discovery of brown adipose tissue in adults stimulates a novel interest for this tissue with high capacity to oxidize fatty acids |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine general. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Clément, Karine. |
| Relator term |
editor. |
|
|---|
| Personal name |
Spiegelman, Bruce M. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783642135163 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-13517-0 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
