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05035nam a22005055i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310150243.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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120130s2012 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783642225178 |
|
978-3-642-22517-8 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH345 |
|
|---|
| Classification number |
QD415-436 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
572 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Berlin, Heidelberg : |
| -- |
Springer Berlin Heidelberg, |
| -- |
2012. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mallick, Bibekanand. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Regulatory RNAs |
| Medium |
[electronic resource] : |
| Remainder of title |
Basics, Methods and Applications / |
| Statement of responsibility, etc |
edited by Bibekanand Mallick, Zhumur Ghosh. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
IX, 552p. 65 illus., 37 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Renaissance of Regulatory RNAs -- Diversity, overlap and relationships in the small RNA landscape -- Fragments of small nucleolar RNAs as a new source for non-coding RNAs -- Small regulatory RNAs (sRNAs) – key players in prokaryotic metabolism, stress response and virulence -- The canonical RNA interference pathway in animals -- Generation of functional long non-coding RNA through transcription and natural selection -- MicroRNA regulation of neuronal differentiation and plasticity -- Long Non-coding RNA Function and Expression in Cancer -- Expression profiling of ncRNAs employing RNP libraries and custom LNA/DNA microarray analysis -- Targeted methods to improve small RNA profiles generated by deep sequencing -- Biocomputational identification of bacterial small RNAs and their target binding sites -- Identifying functional miRNA targets using over-expression and knockdown methods -- Identification of lncRNAs using computational and experimental approaches -- Experimental analyses of RNA-based regulations in Bacteria -- Microregulators ruling over pluripotent stem cells.- The role of RNA-interference in targeting the cancer stem cell and clinical trials for cancer -- microRNAs in development, stem cell differentiation and regenerative medicine -- The role of microRNAs in neurodegenerative diseases: Implications for early detection and treatment -- siRNA therapeutic design: tools and challenges -- Artificial MicroRNA and its Applications -- Deep sequencing of microRNAs in cancer: Expression profiling and its applications. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life sciences. |
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|---|
| Topical term or geographic name as entry element |
Gene expression. |
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| Topical term or geographic name as entry element |
Medicine. |
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|---|
| Topical term or geographic name as entry element |
Biochemistry. |
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| Topical term or geographic name as entry element |
Cytology. |
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| Topical term or geographic name as entry element |
Developmental biology. |
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|---|
| Topical term or geographic name as entry element |
Life Sciences. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry, general. |
|
|---|
| Topical term or geographic name as entry element |
Cell Biology. |
|
|---|
| Topical term or geographic name as entry element |
Gene Expression. |
|
|---|
| Topical term or geographic name as entry element |
Molecular Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Developmental Biology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ghosh, Zhumur. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783642225161 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-22517-8 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
