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003 - CONTROL NUMBER IDENTIFIER |
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005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20140310150245.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9783642377655 |
|
978-3-642-37765-5 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
QR180-189.5 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
616.079 |
Edition number |
23 |
264 #1 - |
-- |
Berlin, Heidelberg : |
-- |
Springer Berlin Heidelberg : |
-- |
Imprint: Springer, |
-- |
2013. |
912 ## - |
-- |
ZDB-2-SBL |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Cullen, Bryan R. |
Relator term |
editor. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
Intrinsic Immunity |
Medium |
[electronic resource] / |
Statement of responsibility, etc |
edited by Bryan R. Cullen. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
VII, 262 p. 23 illus., 22 illus. in color. |
Other physical details |
online resource. |
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
Current Topics in Microbiology and Immunology, |
International Standard Serial Number |
0070-217X ; |
Volume number/sequential designation |
371 |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
The APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response. |
520 ## - SUMMARY, ETC. |
Summary, etc |
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Medicine. |
|
Topical term or geographic name as entry element |
Immunology. |
|
Topical term or geographic name as entry element |
Medical virology. |
|
Topical term or geographic name as entry element |
Microbial genetics. |
|
Topical term or geographic name as entry element |
Plant diseases. |
|
Topical term or geographic name as entry element |
Invertebrates. |
|
Topical term or geographic name as entry element |
Biomedicine. |
|
Topical term or geographic name as entry element |
Immunology. |
|
Topical term or geographic name as entry element |
Virology. |
|
Topical term or geographic name as entry element |
Microbial Genetics and Genomics. |
|
Topical term or geographic name as entry element |
Molecular Medicine. |
|
Topical term or geographic name as entry element |
Plant Pathology. |
|
Topical term or geographic name as entry element |
Invertebrates. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9783642377648 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-37765-5 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |