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03543nam a22004695i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310150246.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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110830s2012 au | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783709104392 |
|
978-3-7091-0439-2 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RM281 |
|
|---|
| Classification number |
QR189-189.5 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
615.372 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Vienna : |
| -- |
Springer Vienna : |
| -- |
Imprint: Springer, |
| -- |
2012. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Thalhamer, Josef. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Gene Vaccines |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XI, 330 p. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Preface -- 1 General mechanisms of gene vaccines -- 2 Strategies to Improve DNA Vaccine Potency: HPV-associated Cervical Cancer as a Model System -- 3 Immune-activating mechanisms of replicase-based DNA and RNA vaccines and their role in immune-apoptosis -- 4 Cytokine genes as molecular adjuvants for DNA vaccines -- 5 Pharmaceutical non-viral formulations for gene vaccines -- 6 Rational design of formulated DNA vaccines: the DermaVir approach -- 7 In vivo electroporation -- 8 Electroporation-based Trigrid™ delivery system (TDS) for DNA vaccine administration -- 9 Prime Boost Regimens for Enhancing Immunity: Magnitude, Quality of Mucosal and Systemic Gene Vaccines -- 10 Intranodal genetic immunization -- 11 Immunotherapy of cancer with RNA vaccines -- 12 DNA and RNA vaccines for prophylactic and therapeutic treatment of type I allergy -- 13 Approved veterinary vaccines – paving the way to products for human use -- 14 Current status of regulations for DNA vaccines -- 15 State of the art production of antibiotic resistance-free plasmid DNA -- 16 Industrial Manufacturing of Plasmid-DNA Products for Gene Vaccination and Therapy. . |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Immunology. |
|
|---|
| Topical term or geographic name as entry element |
Vaccines. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Vaccine. |
|
|---|
| Topical term or geographic name as entry element |
Immunology. |
|
|---|
| Topical term or geographic name as entry element |
Medical Biochemistry. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Weiss, Richard. |
| Relator term |
editor. |
|
|---|
| Personal name |
Scheiblhofer, Sandra. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783709104385 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-7091-0439-2 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
