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Metal Ions in Neurological Systems (Record no. 18295)

000 -LEADER
fixed length control field 04669nam a22004695i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150246.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 121026s2012 au | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783709110010
978-3-7091-1001-0
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QP356.3
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.8042
Edition number 23
264 #1 -
-- Vienna :
-- Springer Vienna :
-- Imprint: Springer,
-- 2012.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Linert, Wolfgang.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Metal Ions in Neurological Systems
Medium [electronic resource] /
Statement of responsibility, etc edited by Wolfgang Linert, Henryk Kozlowski.
300 ## - PHYSICAL DESCRIPTION
Extent XIV, 243 p. 154 illus., 73 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note 1. R.R. Crichton, D.T. Dexter, R.J. Ward: Brain iron metabolism and its perturbation in neurological diseases -- 2. E. Milward et al.: Brain changes in iron loading disorders -- 3. I. Paris, J. Segura-Aguilar: The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease -- 4. E. Siakkou, G.N.L. Jameson: Iron, cysteine and neurodegeneration during Parkinson’s disease -- 5. G. Crisponi et al.: Copper uptake and trafficking in the brain -- 6. Y. Nishida: Prion diseases and manganism -- 7. A. Granzotto, P. Zatta: Metal ions and beta-amyloid: conformational modifications and biological aspects -- 8. A. Granzotto et al.: Beta-amyloid toxicity increases with hydrophobicity in the presence of metal ions -- 9. Ch. Exley, E.R. House: Aluminium in the human brain -- 10. V.M. Nurchi, G. Crisponi, V. Bertolasi, G. Faa, M. Remelli: Aluminium dependent human diseases and chelating properties of aluminium chelatots for bio-medical applications.-11. M. Suwalsky P.L. Henrnandez, C.P. Sotomayor: Aluminum increases toxic effects of amyloid beta-peptides on human erythrocyte membrane and molecular models -- 12. E. Gaggelli, G. Valensin: Oxidative stress in neurodegeneration: targeting mitochondria as a therapeutic aid -- 13. Y. Nishsida: The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders -- 14. O.G. Tsay, K. Kim, D.G. Churchil: Metal ion role in the CNS under toxic organophosphonate exposure: Traces of understanding and various open questions -- 15. S. Casito, M. Aschner: Heavy metals, behavior and neurodegeneration: Using C elegans to untangle a can of warms -- 16. C. Kallay et al.: The effect of point mutations on copper(II) complexes with peptide fragments encompassin the 106-114 region of human prion protein -- 17. E. Sija et al.: Interactions of pyridinecarboxylix acid chelators with brain metal ions: Cu(II), Zn(II), Al(III) -- 18. S. Bohic et al.: Spatially resolved imaging methods to probe metals in brain -- 19. Y. Ha, O. Tsay, D.G. Churchil: ICP-MS for the neurodegenerative and brain sciences.
520 ## - SUMMARY, ETC.
Summary, etc Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Neurochemistry.
Topical term or geographic name as entry element Bioorganic chemistry.
Topical term or geographic name as entry element Chemistry, Organic.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Neurochemistry.
Topical term or geographic name as entry element Neurosciences.
Topical term or geographic name as entry element Organometallic Chemistry.
Topical term or geographic name as entry element Bioorganic Chemistry.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kozlowski, Henryk.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783709110003
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-3-7091-1001-0
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-07AUM Main Library2014-04-07 2014-04-07 E-Book   AUM Main Library612.8042