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Influenza Virus Sialidase - A Drug Discovery Target (Record no. 18313)

000 -LEADER
fixed length control field 02998nam a22004695i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150246.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 110830s2012 sz | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783764389277
978-3-7643-8927-7
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RM1-950
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615
Edition number 23
264 #1 -
-- Basel :
-- Springer Basel,
-- 2012.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Itzstein, Mark.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Influenza Virus Sialidase - A Drug Discovery Target
Medium [electronic resource] /
Statement of responsibility, etc edited by Mark Itzstein.
300 ## - PHYSICAL DESCRIPTION
Extent IX, 178p. 58 illus., 21 illus. in color.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Milestones in Drug Therapy
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Influenza Virus Virology -- Investigating the interaction between influenza and sialic acid – making and breaking the link -- Enzymology of Influenza Virus Sialidase -- Influenza Virus Sialidase and Structure-Based Drug Design -- The Development of Carbohydrate-based Influenza Virus Sialidase Inhibitors -- The Development of Non-carbohydrate-based Influenza Virus Sialidase Inhibitors -- Clinical Experience with Influenza Virus Sialidase Inhibitors -- Resistance Development to Influenza Virus Sialidase Inhibitors.
520 ## - SUMMARY, ETC.
Summary, etc Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Immunology.
Topical term or geographic name as entry element Toxicology.
Topical term or geographic name as entry element Medical virology.
Topical term or geographic name as entry element Emerging infectious diseases.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Pharmacology/Toxicology.
Topical term or geographic name as entry element Infectious Diseases.
Topical term or geographic name as entry element Virology.
Topical term or geographic name as entry element Immunology.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783764389260
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-3-7643-8927-7
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-07AUM Main Library2014-04-07 2014-04-07 E-Book   AUM Main Library615