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Mechanosensitivity and Mechanotransduction (Record no. 18551)

000 -LEADER
fixed length control field 06545nam a22004815i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150249.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 101118s2011 ne | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9789048198818
978-90-481-9881-8
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QH573-671
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 571.6
Edition number 23
264 #1 -
-- Dordrecht :
-- Springer Netherlands,
-- 2011.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Kamkin, Andre.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Mechanosensitivity and Mechanotransduction
Medium [electronic resource] /
Statement of responsibility, etc edited by Andre Kamkin, Irina Kiseleva.
300 ## - PHYSICAL DESCRIPTION
Extent XXIV, 371 p.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Mechanosensitivity in Cells and Tissues ;
Volume number/sequential designation 4
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Foreword by Holger Scholz -- Editorial: Basic principles of mechanosensing and mechanotransduction in cells, Andre Kamkin and Irina Kiseleva -- List of Contributors -- Part I The Role of Cytoskeleton in Mechanosensitivity and Mechanotransduction: 1. Integrin-mediated mechanotransduction in vascular smooth muscle cells, Kay-Pong Yip, Lavanya Balasubramanian, James S. K. Sham -- 2. The role of actin cytoskeleton in mechanosensation, Tianzhi Luo and Douglas N. Robinson -- 3. Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts, Qiang Fu, Changjing Wu, Yourui Li, Yiping Zhang -- 4. Involvement of the cytoskeletal elements in articular cartilage mechanotransduction, Emma J Blain -- Part II Molecular Mechanisms of Mechanotransduction and Ion Channels Modifiers : 5. The role of nitric oxide in regulation of mechanically gated channels in the heart, Victor Kazanski, Andre Kamkin, Ekaterina Makarenko, Natalia Lysenko, Natalia Lapina, and Irina Kiseleva -- 6. Role of signaling pathways in the myocardial response to biomechanical stress and in mechanotransduction in the heart, Danny Guo, Zamaneh Kassiri, and Gavin Y. Oudit -- 7. Atomistic molecular simulation of gating modifier venom peptides - two binding modes and effects of lipid structure, Kazuhisa Nishizawa -- Part III Mechanosensing and Mechanotransduction in Vascular Cells: 8. Cellular and molecular effects of mechanical stretch on vascular cells, Kou-Gi Shyu -- 9. Role of Proteoglycans in Vascular Mechanotransduction, Aaron B. Baker -- Part IV Mechanotransduction in the Lung: 10. Control of TRPV4 and its effect on the lung, James C. Parker and Mary I Townsley -- 11. The Role of Protein-protein Interactions in Mechanotransduction: Implications in Ventilator Induced Lung Injury, Matt Rubacha and Mingyao Liu -- Part V Mechanosensing and Mechanotransduction in Bone and Joint Tissues: 12. Cellular mechanisms of mechanotransduction in bone, Suzanne R.L. Young and Fredrick M. Pavalko -- 13. The mechanosensitivity of cells in joint tissues: Role in the pathogenesis of joint diseases, Christelle Sanchez, Marianne Mathy-Hartert, Yves Henrotin -- Part VI Mechanosensitivity of Sensor Systems: 14. Primary Cilia are Mechanosensory Organelles in Vestibular Tissues, Surya Nauli -- Part VII Mechanosensing and Mechanotransduction in Blood Cells: 15. Mechanosensitive K+ Channels in Mouse B Lymphocytes: PLC-mediated Release of TREK-2 from Inhibition by PIP2, Sung Joon Kim and Joo Hyun Nam -- Index.
520 ## - SUMMARY, ETC.
Summary, etc This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It  contains a detailed description of several  stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of  nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii  cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume  highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies.  This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Life sciences.
Topical term or geographic name as entry element Human physiology.
Topical term or geographic name as entry element Cardiology.
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Cytology.
Topical term or geographic name as entry element Life Sciences.
Topical term or geographic name as entry element Cell Biology.
Topical term or geographic name as entry element Medical Biochemistry.
Topical term or geographic name as entry element Human Physiology.
Topical term or geographic name as entry element Cardiology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kiseleva, Irina.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789048198801
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-90-481-9881-8
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-08AUM Main Library2014-04-08 2014-04-08 E-Book   AUM Main Library571.6
Languages: 
English |
العربية