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Mast Cells and Tumours (Record no. 18667)

000 -LEADER
fixed length control field 04989nam a22004575i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150251.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 110621s2011 ne | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9789400714694
978-94-007-1469-4
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC261-271
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
264 #1 -
-- Dordrecht :
-- Springer Netherlands :
-- Imprint: Springer,
-- 2011.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Ribatti, Domenico.
Relator term author.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Mast Cells and Tumours
Medium [electronic resource] :
Remainder of title from Biology to Clinic /
Statement of responsibility, etc by Domenico Ribatti, Enrico Crivellato.
300 ## - PHYSICAL DESCRIPTION
Extent VIII, 142p. 28 illus., 18 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Introduction -- 1. The mast cell -- 1.1. A historical overview -- 1.2. Biology of mast cells -- 2. Mast cell mediators -- 2.1. Granule composition -- 2.2. Histamine and serotonin -- 2.3. Proteases -- 2.4. Lipid mediators -- 2.5. Cytokines and growth factors -- 2.6. Chemokines -- 3. The tumour cell -- 3.1. Biology of tumour cell -- 3.2. The importance of microenvironment in tumor metastasis -- 3.3. The “seed and soil” theory -- 4. Tumour angiogenesis -- 4.1. The angiogenic switch -- 4.2. Phenotypic and genotypic characteristics of tumor vessels and genetic evidence that tumours are angiogenesis-dependent -- 4.3.             What is the evidence that genetic instability promotes the angiogenic switch? -- 4.4. Hypoxic regulation of tumour angiogenesis -- 4.5.  The role of pericytes in tumour angiogenesis -- 4.6.   The role of inflammatory cells in tumour angiogenesis -- 4.7.         Participation of hematopoietic cells and endothelial precursor cells to tumour angiogenesis -- 4.8.  Alternative mechanisms of tumour angiogenesis -- 4.9.   Vascular cooption -- 4.10. The prognostic significance of tumour angiogenesis -- 4.11. Angiogenesis is not necessarily involved in tumour progression -- 5. Mast cells and tumours -- 5.1. Mast cells and tumour growth in humans: pro and contra -- 6. Mast cells and tumour angiogenesis -- 6.1.            Mast cell-induced angiogenesis studied by means of in vitro and in vivo assays -- 6.2. Mast cell-induced angiogenesis studied by means of experimental carcinogenesis -- 6.3.           Angiogenic factors stored in mast cells -- 6.4. Mast cells and angiogenesis in human solid tumours -- 6.5. Mast cells and angiogenesis in human hematological tumours -- 7. Mast cells and tumour lymphangiogenesis -- 8. Drug affecting mast cells -- Concluding remarks and perspectives -- References.  .
520 ## - SUMMARY, ETC.
Summary, etc Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Pathology.
Topical term or geographic name as entry element Cytology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Pathology.
Topical term or geographic name as entry element Cell Biology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Crivellato, Enrico.
Relator term author.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789400714687
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-94-007-1469-4
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-08AUM Main Library2014-04-08 2014-04-08 E-Book   AUM Main Library614.5999
Languages: 
English |
العربية