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| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310150251.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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111122s2012 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9789400728165 |
|
978-94-007-2816-5 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QH588.S83 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
571.6 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Dordrecht : |
| -- |
Springer Netherlands, |
| -- |
2012. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Heine, Vivi M. |
| Relator term |
author. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Induced Pluripotent Stem Cells in Brain Diseases |
| Medium |
[electronic resource] : |
| Remainder of title |
Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine. / |
| Statement of responsibility, etc |
by Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XV, 59p. 7 illus., 6 illus. in color. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
SpringerBriefs in Neuroscience, |
| International Standard Serial Number |
2191-558X |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
I. Introduction.- II. Cell Reprogramming: A New Era in Regenerative Medicine -- a. Stem Cells -- b. Reprogramming Methods.- c. Measuring Pluripotency, Efficiency, and Identity -- d. Induced Pluripotent Stem Cells versus Embryonic Stem Cells -- III. Understanding Epigenetic Memory is the Key to Successful Reprogramming -- a. Pre-fertilization to Embryo -- b. Epigenetic Control in De-, Re-, and Trans-differentiation -- IV. Prospects for Cell Replacement Therapies for Brain Diseases -- a. Parkinson’s Disease -- b. Childhood Brain White Matter Disorders -- V. Conclusions.- VI. Acknowledgement -- VII. References. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement material, scientists confront the fundamental issues of cellular identity and plasticity. The basis of this book is formed by the theses of three talented master students: Stephanie Dooves, Dwayne Holmes and Judith Wagner. Their work discusses the recent advancements in the field of cell reprogramming. Although it is clear that we can produce pluripotent stem cells from differentiated cells, there are still a lot of unsolved issues. These issues include the efficiency and safety of reprogramming, the similarity of induced pluripotent (iPSCs) to embryonic stem cells (ESCs) and the epigenetic status of the cells. In the third chapter, the use of stem cell therapy for brain diseases will be discussed, with a focus on Parkinson’s disease (PD) and Vanishing White Matter (VWM). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Life sciences. |
|
|---|
| Topical term or geographic name as entry element |
Neurosciences. |
|
|---|
| Topical term or geographic name as entry element |
Neurology. |
|
|---|
| Topical term or geographic name as entry element |
Pediatrics. |
|
|---|
| Topical term or geographic name as entry element |
Stem cells. |
|
|---|
| Topical term or geographic name as entry element |
Life Sciences. |
|
|---|
| Topical term or geographic name as entry element |
Stem Cells. |
|
|---|
| Topical term or geographic name as entry element |
Neurology. |
|
|---|
| Topical term or geographic name as entry element |
Pediatrics. |
|
|---|
| Topical term or geographic name as entry element |
Neurosciences. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dooves, Stephanie. |
| Relator term |
author. |
|
|---|
| Personal name |
Holmes, Dwayne. |
| Relator term |
author. |
|
|---|
| Personal name |
Wagner, Judith. |
| Relator term |
author. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9789400728158 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-94-007-2816-5 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
