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Advances in Mitochondrial Medicine (Record no. 18748)

000 -LEADER
fixed length control field 04993nam a22004935i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150251.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120308s2012 ne | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9789400728691
978-94-007-2869-1
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number R-RZ
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 610
Edition number 23
264 #1 -
-- Dordrecht :
-- Springer Netherlands,
-- 2012.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Scatena, Roberto.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Advances in Mitochondrial Medicine
Medium [electronic resource] /
Statement of responsibility, etc edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina.
300 ## - PHYSICAL DESCRIPTION
Extent XII, 461p. 62 illus., 28 illus. in color.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Advances in Experimental Medicine and Biology,
International Standard Serial Number 0065-2598 ;
Volume number/sequential designation 942
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Section I – Physiology and structure of Mitochondria -- 1.               The oxidative phosphorylation system in mammalian mitochondria -- 2. Physiology and pathophysiology of mitochondrial DNA -- 3. Mitochondrial calcium as a key regulator of mitochondrial activities -- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology -- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology? -- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects -- 7. The mitochondrial pathways of apoptosis -- Section II – Mitochondria and disease -- 8. Inherited mitochondrial disorders -- 9. Mitochondria and metabolism diseases -- 10. Mitochondria and diabetes. An intriguing pathogenetic role -- 11. Mitochondria and heart diseases -- 12. Mitochondria in neurodegeneration -- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation -- Section III – Mitochondria and Aging -- 14.Mitochondria and aging -- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors -- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms -- 18. Anthracyclines and mitochondria -- Section IV-  Applications of Mitochondrial science -- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer -- 20. Mitochondria in Anthropology and forensic medicine.  .
520 ## - SUMMARY, ETC.
Summary, etc Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Toxicology.
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Biomedicine general.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Molecular Medicine.
Topical term or geographic name as entry element Pharmacology/Toxicology.
Topical term or geographic name as entry element Medical Biochemistry.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bottoni, Patrizia.
Relator term editor.
Personal name Giardina, Bruno.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789400728684
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-94-007-2869-1
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-08AUM Main Library2014-04-08 2014-04-08 E-Book   AUM Main Library610
Languages: 
English |
العربية