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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310150252.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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120726s2013 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9789400745902 |
|
978-94-007-4590-2 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
R-RZ |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
610 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Dordrecht : |
| -- |
Springer Netherlands : |
| -- |
Imprint: Springer, |
| -- |
2013. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mathews, Lesley A. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
DNA Repair of Cancer Stem Cells |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Lesley A Mathews, Stephanie M Cabarcas, Elaine M. Hurt. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
VI, 178 p. 10 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Preface. -1 Introduction to Cancer stem cells.-2 DNA Repair Pathways and Mechanisms.-3 Resistance and DNA repair mechanisms of cancer stem cells: Potential molecular targets for therapy.-4 DNA Repair in Normal Stem Cells.-5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells.-6 DNA Repair Mechanisms in Breast Cancer Stem Cells.7 DNA Repair Mechanisms in other Cancer Stem Cell models -- 8 Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair.-9 Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for new therapeutics -- 10 The Future of DNA Repair and Cancer Stem Cells. Index. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Oncology. |
|
|---|
| Topical term or geographic name as entry element |
Stem cells. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine general. |
|
|---|
| Topical term or geographic name as entry element |
Molecular Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Cancer Research. |
|
|---|
| Topical term or geographic name as entry element |
Stem Cells. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Cabarcas, Stephanie M. |
| Relator term |
editor. |
|
|---|
| Personal name |
Hurt, Elaine M. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9789400745896 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-94-007-4590-2 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
