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Regulated Proteolysis in Microorganisms (Record no. 18897)

000 -LEADER
fixed length control field 04607nam a22004695i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150254.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130321s2013 ne | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9789400759404
978-94-007-5940-4
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number R-RZ
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 610
Edition number 23
264 #1 -
-- Dordrecht :
-- Springer Netherlands :
-- Imprint: Springer,
-- 2013.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Dougan, David A.
Relator term editor.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Regulated Proteolysis in Microorganisms
Medium [electronic resource] /
Statement of responsibility, etc edited by David A. Dougan.
300 ## - PHYSICAL DESCRIPTION
Extent XIV, 333 p. 65 illus., 62 illus. in color.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Subcellular Biochemistry,
International Standard Serial Number 0306-0225 ;
Volume number/sequential designation 66
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Machines of destruction - AAA+ proteases and the adaptors that control them -- The AAA+ protease Lon -- FtsH protease-mediated regulation of various cellular functions -- Regulated proteolysis in Bacillus subtilis -- Regulation of stress response pathways in Escherichia coli by proteolysis -- Regulation of the SigmaE stress response -- Pathogenic bacteria: protein degradation and virulence -- Roles of Cdc48 in regulated protein degradation in yeast -- The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis & activity control -- PUPylation and Mycobacteria -- Archea proteasomes and SAMPylation.
520 ## - SUMMARY, ETC.
Summary, etc This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker’s yeast Saccharomyces cerevisiae).     For many years, intracellular protein degradation was almost exclusively thought of as a non-selective mechanism to recycle amino acids and remove trash from the cell. The contemporary view however, is that protein degradation is a highly selective process that plays a key role in a number of important cellular processes. Not only does it contribute to the maintenance of protein homeostasis (proteostasis) through the direct recognition and removal of damaged proteins, but it also regulates the cells response to a variety of environmental stress signals. Regulatory proteolysis also plays an important role in virulence of pathogenic bacteria, and “fitness” of eukaryotic organelles. This book focuses on the central players in these diverse cellular processes – the AAA+ proteases – and examines how these machines achieve their exquisite specificity. It also highlights the various mechanisms microorganisms use to post-translationally modify their proteins, as a means to regulate protein levels and hence cell physiology.       Regulated proteolysis in microorganisms is a must read for researchers working on protein homeostasis, stress response pathways and virulence. It provides a detailed overview of the components and signals that contribute to the metabolic stability of a protein in various microorganisms. As such, it also forms a useful resource for researchers in biotechnology. The book is essential reading for senior undergraduate and postgraduate students, studying all areas of protein science including protein chemistry, biochemistry, molecular biology, microbiology and biotechnology.     Key features and content:   ·           Molecular mechanism of action of AAA+ proteases ·           Control of substrate specificity by adaptor proteins ·           Post-translational tagging of proteins as a means to control their metabolic stability (SsrA, Ubiquitlyation, PUPylation and SAMPylation) ·           Regulation of stress response pathways by proteolysis ·           Regulated degradation and virulence ·           Protein degradation within mitochondria
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Science (General).
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Microbiology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Biomedicine general.
Topical term or geographic name as entry element Microbiology.
Topical term or geographic name as entry element Protein Structure.
Topical term or geographic name as entry element Protein Science.
Topical term or geographic name as entry element Science, general.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789400759398
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-94-007-5940-4
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-08AUM Main Library2014-04-08 2014-04-08 E-Book   AUM Main Library610
Languages: 
English |
العربية