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The Tumor Immunoenvironment (Record no. 18914)

000 -LEADER
fixed length control field 05872nam a22004815i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310150254.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130321s2013 ne | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9789400762176
978-94-007-6217-6
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC261-271
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
264 #1 -
-- Dordrecht :
-- Springer Netherlands :
-- Imprint: Springer,
-- 2013.
912 ## -
-- ZDB-2-SBL
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Shurin, Michael R.
Relator term editor.
245 14 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title The Tumor Immunoenvironment
Medium [electronic resource] /
Statement of responsibility, etc edited by Michael R. Shurin, Viktor Umansky, Anatoli Malyguine.
300 ## - PHYSICAL DESCRIPTION
Extent XVI, 745 p. 51 illus., 46 illus. in color.
Other physical details online resource.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface -- Introduction -- Role of the immunological environment in cancer initiation, development and progression -- Part I Tumor Microenvironment and Immunoenvironment -- The metastatic microenvironment -- Tumor infiltration by immune cells: pathologic evaluation and a clinical significance -- Immunologic interpretation of cancer biology: impact on clinical outcome -- Part II Developmental Characteristics of the Tumor ImmunoEnvironment -- Development of antitumor cellular immunity -- The versatile world of inflammatory chemokines in cancer.-Inflammation, Tumor Progression, and Immune Suppression -- Pleiotropic and differential functions of IL-1a and IL-1b shape the tumor microenvironment and affect the outcome of malignancies -- Impact of obesity and aging on the tumor immunoenvironment -- Part III Tumor Escape from Immune Recognition -- MHC class I antigens and the tumor microenvironment -- Tumor-produced immune regulating factors -- Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments.- T cell malfunction in the tumor environment -- Signaling of tumor-induced immunosuppression of dendritic cells -- Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells -- Part IV  Immune Regulators in the Tumor ImmunoEnvironment -- The role of myeloid-derived suppressor cells in cancer -- Macrophage differentiation and activation states in the tumor microenvironment -- Dendritic cells and cancer: development, dysfunction and therapeutic targets -- The role of tumor-associated neutrophils in cancer -- Mast cell modulation of the tumor microenvironment -- Regulatory T cells in patients with cancer -- Tumor-evoked regulatory B cells as important mediators of cancer escape -- Part V  Tumor Escape and Cancer Immunotherapy -- Cancer immunotherapy: Overview in brief -- Programming of MDSC: New opportunities for targeted therapy -- Therapeutic targeting regulatory T cells in tumor.-ChemoImmunoModulation: Focus on myeloid regulatory cells -- Combining vaccines with therapies that render tumor cells more susceptible to        immune mediated killing -- Prophylactic Cancer Vaccines -- Part VI  Analyzing Immune Responses in Cancer -- Approaches to Immunologic Monitoring of Clinical Trials -- Evaluation of the tumor immunoenvironment in clinical trials -- Analysis of Myeloid-derived Suppressor Cells in Patients with Cancer -- When results of T cell immune monitoring match or do not match clinical outcomes of tumor vaccine trials - what more could and should we measure?.
520 ## - SUMMARY, ETC.
Summary, etc Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in the tumor microenvironment. The balance between immune cells that support tumor progression and immune cells that sustain tumor-controlling immune surveillance is tightly regulated by various factors originated from both the malignant and non-cancerous cells in the tumor microenvironment. Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor ImmunoEnvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions. Moreover, it is discussed how these interactions evolve during cancer progression and in response to different kinds of anticancer therapy. It is anticipated that the book will attract many researchers and clinicians in the field of basic and applied tumor immunobiology and open new opportunities for collaborative programs aiming at the development of effective and feasible therapeutic approaches to cancer treatment.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Immunology.
Topical term or geographic name as entry element Life sciences.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Immunology.
Topical term or geographic name as entry element Life Sciences, general.
Topical term or geographic name as entry element Biomedicine general.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Umansky, Viktor.
Relator term editor.
Personal name Malyguine, Anatoli.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789400762169
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-94-007-6217-6
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-08AUM Main Library2014-04-08 2014-04-08 E-Book   AUM Main Library614.5999
Languages: 
English |
العربية