| 000 -LEADER |
|---|
| fixed length control field |
03901nam a22004695i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140310150254.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
130618s2013 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9789400763319 |
|
978-94-007-6331-9 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
R-RZ |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
610 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Dordrecht : |
| -- |
Springer Netherlands : |
| -- |
Imprint: Springer, |
| -- |
2013. |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Capelluto, Daniel G.S. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Lipid-mediated Protein Signaling |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Daniel G.S. Capelluto. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIII, 219 p. 44 illus., 28 illus. in color. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Advances in Experimental Medicine and Biology, |
| International Standard Serial Number |
0065-2598 ; |
| Volume number/sequential designation |
991 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Sphingomyelin and its role in cellular signaling -- The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains -- The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition -- Phosphoinositides and PDZ Domain Scaffolds -- PtdIns(4)P signalling and recognition systems -- PtdIns(4,5)P2-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism -- Role of Phosphatidylinositol 3,4,5-trisphosphate in Cell Signaling -- The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling -- Phosphatidic Acid-Mediated Signaling -- Phosphatidylserine-mediated cellular signaling -- Cardiolipin-mediated cellular signaling. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Lipids are no longer seen as molecules that only provide membrane structure and organization. Due to their amphipathic nature, lipids are localized both on the surface and internally in membranes in the cell, and at these locations, trigger signaling pathways by interacting with soluble proteins, typically through lipid-interacting domains and motifs. More importantly, interconversion of lipid species in these compartments is fundamental, not only by sustaining signaling but also by contributing to signaling pathways that link protein receptors with intracellular effectors. With contributions from eleven leading research teams, this book updates the most recent findings associated with lipid-mediated cell signaling in mammals and plants. Contributors give comprehensive overviews of the physiological role of sphingolipids and phospholipids and how they undergo synthesis and turnover. Emphasis on the structural aspects of protein-lipid interactions is compiled in several chapters with great detail, whereas fully described mechanisms of lipid-mediated membrane targeting and insertion are considered in others. Authors also discuss models and techniques used to characterize lipid-mediated membrane binding of proteins. In addition, several chapters highlight the correlation of abnormal intracellular levels of lipids with human diseases, thus, making this book a valuable resource for biochemists, biophysicists, cell biologists, and clinical scientists with interest in lipid-mediated signaling pathways. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Spectroscopy. |
|
|---|
| Topical term or geographic name as entry element |
Data structures (Computer science). |
|
|---|
| Topical term or geographic name as entry element |
Life sciences. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine general. |
|
|---|
| Topical term or geographic name as entry element |
Life Sciences, general. |
|
|---|
| Topical term or geographic name as entry element |
Spectroscopy/Spectrometry. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine general. |
|
|---|
| Topical term or geographic name as entry element |
Data Structures. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9789400763302 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-94-007-6331-9 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
