| 000 -LEADER |
|---|
| fixed length control field |
03473nam a22004695i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140310150655.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100301s2010 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783642043024 |
|
978-3-642-04302-4 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RC648-665.2 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.4 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Berlin, Heidelberg : |
| -- |
Springer Berlin Heidelberg, |
| -- |
2010. |
| 912 ## - |
|---|
| -- |
ZDB-2-SME |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Clemmons, David. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
IGFs:Local Repair and Survival Factors Throughout Life Span |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by David Clemmons, Iain C.A.F. Robinson, Yves Christen. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Research and Perspectives in Endocrine Interactions, |
| International Standard Serial Number |
1861-2253 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
GH & IGF1: Aspects of Global and Local Release and Actions -- Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation -- IGFBP2 Supports ex vivo Expansion of Hematopoietic Stem Cells -- The Role of Insulin-like Growth Factor-I in Central Nervous System Development -- Stimulation of Proliferative Pathways by IGF-binding Proteins -- Signaling Pathways that Regulate C. elegans Life Span -- IGF-1 Regulation of Skeletal Muscle Hypertrophy and Atrophy -- Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer -- The Functions of Insulin-like Peptides in Insects -- IGF Receptors in the Adult Brain -- The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Medical genetics. |
|
|---|
| Topical term or geographic name as entry element |
Human physiology. |
|
|---|
| Topical term or geographic name as entry element |
Endocrinology. |
|
|---|
| Topical term or geographic name as entry element |
Medicine & Public Health. |
|
|---|
| Topical term or geographic name as entry element |
Endocrinology. |
|
|---|
| Topical term or geographic name as entry element |
Human Physiology. |
|
|---|
| Topical term or geographic name as entry element |
Gene Function. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Robinson, Iain C.A.F. |
| Relator term |
editor. |
|
|---|
| Personal name |
Christen, Yves. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783642043017 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-04302-4 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
