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| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20140310150659.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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120903s2013 au | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783709111253 |
|
978-3-7091-1125-3 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RC109-216 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.9 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Vienna : |
| -- |
Springer Vienna : |
| -- |
Imprint: Springer, |
| -- |
2013. |
| 912 ## - |
|---|
| -- |
ZDB-2-SME |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ponte-Sucre, Alicia. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Drug Resistance in Leishmania Parasites |
| Medium |
[electronic resource] : |
| Remainder of title |
Consequences, Molecular Mechanisms and Possible Treatments / |
| Statement of responsibility, etc |
edited by Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIV, 459 p. 44 illus., 24 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Foreword -- Introduction. Leishmaniasis, the biology of a parasite. Alicia Ponte Sucre -- I Determinant features in leishmaniasis -- 1 Molecular evolution and phylogeny of Leishmania. Gabriele Schoenian, Elisa Cupolillo, Isabel Mauricio -- 2 The role of reservoirs: Canine leishmaniasis. Lenea Campino, Carla Maia -- 3 Epidemiology of leishmaniasis in the time of drug resistance. Jean Claude Dujardin, Saskya Decuypere -- II Leishmania and the immune system -- 4 The role of the immune system in resistance to infection. Lukasz Kedzierski, Krystal J. Evans -- 5 Vaccination as a control measure. Katrin Färber , Heidrun Moll -- 6 Leishmania vaccines: Past, Present and Future. Bhavana Sethu Lakshmi, Rentala Madhubala -- III Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance -- 7 Co-infection with HIV. Margriet den Boer, Luis Rivas, Jorge Alvar -- 8 Visceral leishmaniasis. Shyam Sundar , J aya Chakravarty -- 9 American Tegumentary leishmaniasis. Olga Zerpa, Alicia Ponte-Sucre -- IV Molecular features of drug-resistant Leishmania -- 10 Genetic expression and drug resistance, the role of proteomics. Patricia Cuervo, Jose Batista de Jesus -- 11 The role of ABC transporters in drug-resistant Leishmania. Adriano C Coelho, Paulo C Cotrim -- 12 Functional analysis of Leishmania membrane (non ABC) transporters involved in drug resistance. Scott M Landfear -- 13 Intracellular mechanisms of resistance in Leishmania -- V Pharmacology and chemotherapy of leishmaniasis. Mitali Chatterjee -- 14 Classical vs new Treatment regimens. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley -- 15 Drug targets, drug effectors and drug targeting and delivery. Philippe M Loiseau, Gillian Barratt -- 16 Mechanisms of miltefosine resistance in Leishmania. Francisco Gamarro, María P Sánchez-Cañete, Santiago Castanys -- 17 P-glycoprotein-like transporters in Leishmania: a search for reversal agents. Bruno Pradines -- VI Strategies to circumvent drug resistance in Leishmania -- 18 The relevance of susceptibility tests, breakpoints and markers. Louis Maes, Paul Cos and Simon Croft -- 19 The Concept of Fitness and drug resistance in Leishmania. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Vaccines. |
|
|---|
| Topical term or geographic name as entry element |
Drug interactions. |
|
|---|
| Topical term or geographic name as entry element |
Medical parasitology. |
|
|---|
| Topical term or geographic name as entry element |
Pharmaceutical technology. |
|
|---|
| Topical term or geographic name as entry element |
Emerging infectious diseases. |
|
|---|
| Topical term or geographic name as entry element |
Microbiology. |
|
|---|
| Topical term or geographic name as entry element |
Medicine & Public Health. |
|
|---|
| Topical term or geographic name as entry element |
Infectious Diseases. |
|
|---|
| Topical term or geographic name as entry element |
Drug Resistance. |
|
|---|
| Topical term or geographic name as entry element |
Pharmaceutical Sciences/Technology. |
|
|---|
| Topical term or geographic name as entry element |
Vaccine. |
|
|---|
| Topical term or geographic name as entry element |
Parasitology. |
|
|---|
| Topical term or geographic name as entry element |
Microbiology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Diaz, Emilia. |
| Relator term |
editor. |
|
|---|
| Personal name |
Padrón-Nieves, Maritza. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783709102381 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-7091-1125-3 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
