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Multistate GTPase Control Co-translational Protein Targeting (Record no. 27450)

000 -LEADER
fixed length control field 02760nam a22004695i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310153326.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 110927s2012 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781441978080
978-1-4419-7808-0
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QD241-441
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 547
Edition number 23
264 #1 -
-- Boston, MA :
-- Springer US,
-- 2012.
912 ## -
-- ZDB-2-CMS
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Zhang, Xin.
Relator term author.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Multistate GTPase Control Co-translational Protein Targeting
Medium [electronic resource] /
Statement of responsibility, etc by Xin Zhang.
300 ## - PHYSICAL DESCRIPTION
Extent VII, 96p. 46 illus., 31 illus. in color.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Springer Theses
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Introduction -- A Multistep Mechanism for Assembly of the SRP-SR Complex -- Dynamics of the Transient Intermediate during SRP-SR Association -- Multiple Conformational Switches Control Cotranslational Protein Targeting -- Sequential Checkpoints Govern Substrate Selection during Cotranslational Protein Targeting.
520 ## - SUMMARY, ETC.
Summary, etc Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Chemistry.
Topical term or geographic name as entry element Analytical biochemistry.
Topical term or geographic name as entry element Bioorganic chemistry.
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Proteomics.
Topical term or geographic name as entry element Chemistry.
Topical term or geographic name as entry element Bioorganic Chemistry.
Topical term or geographic name as entry element Proteomics.
Topical term or geographic name as entry element Analytical Chemistry.
Topical term or geographic name as entry element Biochemistry, general.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9781441978073
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-4419-7808-0
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-14AUM Main Library2014-04-14 2014-04-14 E-Book   AUM Main Library547