000 -LEADER |
fixed length control field |
02760nam a22004695i 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20140310153326.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
fixed length control field |
cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
110927s2012 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781441978080 |
|
978-1-4419-7808-0 |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
QD241-441 |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
547 |
Edition number |
23 |
264 #1 - |
-- |
Boston, MA : |
-- |
Springer US, |
-- |
2012. |
912 ## - |
-- |
ZDB-2-CMS |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Zhang, Xin. |
Relator term |
author. |
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
Title |
Multistate GTPase Control Co-translational Protein Targeting |
Medium |
[electronic resource] / |
Statement of responsibility, etc |
by Xin Zhang. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
VII, 96p. 46 illus., 31 illus. in color. |
Other physical details |
online resource. |
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
Springer Theses |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Introduction -- A Multistep Mechanism for Assembly of the SRP-SR Complex -- Dynamics of the Transient Intermediate during SRP-SR Association -- Multiple Conformational Switches Control Cotranslational Protein Targeting -- Sequential Checkpoints Govern Substrate Selection during Cotranslational Protein Targeting. |
520 ## - SUMMARY, ETC. |
Summary, etc |
Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Chemistry. |
|
Topical term or geographic name as entry element |
Analytical biochemistry. |
|
Topical term or geographic name as entry element |
Bioorganic chemistry. |
|
Topical term or geographic name as entry element |
Biochemistry. |
|
Topical term or geographic name as entry element |
Proteomics. |
|
Topical term or geographic name as entry element |
Chemistry. |
|
Topical term or geographic name as entry element |
Bioorganic Chemistry. |
|
Topical term or geographic name as entry element |
Proteomics. |
|
Topical term or geographic name as entry element |
Analytical Chemistry. |
|
Topical term or geographic name as entry element |
Biochemistry, general. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Printed edition: |
International Standard Book Number |
9781441978073 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4419-7808-0 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
E-Book |