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| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310153327.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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120713s2012 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781461438281 |
|
978-1-4614-3828-1 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QD96.M3 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
543.65 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Boston, MA : |
| -- |
Springer US : |
| -- |
Imprint: Springer, |
| -- |
2012. |
| 912 ## - |
|---|
| -- |
ZDB-2-CMS |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Xu, Q. Alan. |
| Relator term |
editor. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
LC-MS in Drug Bioanalysis |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Q. Alan Xu, Timothy L. Madden. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XI, 469 p. 118 illus., 30 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Internal standards for quantitative LC-MS bioanalysis -- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS -- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry -- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry -- Pitfalls of LC-MS/MS in the clinical laboratory -- Therapeutic drug monitoring to support clinical pharmacogenomics -- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices -- The analysis of antipsychotic drugs in human biosamples by LC-MS -- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective -- Applications of mass spectrometry in analyses of steroid hormones -- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications -- Analysis of illicit drugs in human biological samples by LC-MSn -- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs -- A planar integrated micro mass spectrometer. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, toxicology, and drug discovery and development. LC-MS in Drug Bioanalysis offers discussions on: ● LC-MS/MS method development and validation in a regulated environment ● Internal standard use in LC-MS/MS bioanalysis ● Pitfalls of LC-MS/MS and how to overcome them ● Dried blood spot sampling ● Microflow LC-MS/MS ● LC-MS/MS in therapeutic drug monitoring ● Applications of LC-MS/MS in drug bioanalysis This book will aid readers to improve their skills in LC-MS/MS method development, validation, and applications in the analysis of drugs and their metabolites in complex biological matrices. In addition, this book provides detailed information on the bioanalysis of antidepressants, antipsychotics, steroid hormones, anticancer agents, and drugs of abuse. Newer methodologies are discussed including the use of unique sample preparation techniques and the implementation of imaging mass spectrometry in the localization of drug and drug metabolites in tissues. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Chemistry. |
|
|---|
| Topical term or geographic name as entry element |
Toxicology. |
|
|---|
| Topical term or geographic name as entry element |
Analytical biochemistry. |
|
|---|
| Topical term or geographic name as entry element |
Mass spectrometry. |
|
|---|
| Topical term or geographic name as entry element |
Chromatography. |
|
|---|
| Topical term or geographic name as entry element |
Chemistry. |
|
|---|
| Topical term or geographic name as entry element |
Mass Spectrometry. |
|
|---|
| Topical term or geographic name as entry element |
Analytical Chemistry. |
|
|---|
| Topical term or geographic name as entry element |
Pharmacology/Toxicology. |
|
|---|
| Topical term or geographic name as entry element |
Chromatography. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Madden, Timothy L. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9781461438274 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4614-3828-1 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
