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Heteroaromatic Lipoxin A4 Analogues (Record no. 27871)

000 -LEADER
fixed length control field 02530nam a22004575i 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140310153332.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120109s2012 gw | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783642246326
978-3-642-24632-6
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QD241-441
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 547
Edition number 23
264 #1 -
-- Berlin, Heidelberg :
-- Springer Berlin Heidelberg,
-- 2012.
912 ## -
-- ZDB-2-CMS
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Duffy, Colm.
Relator term author.
245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE
Title Heteroaromatic Lipoxin A4 Analogues
Medium [electronic resource] :
Remainder of title Synthesis and Biological Evaluation /
Statement of responsibility, etc by Colm Duffy.
300 ## - PHYSICAL DESCRIPTION
Extent XXII, 130 p.
Other physical details online resource.
440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Springer Theses
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.
520 ## - SUMMARY, ETC.
Summary, etc In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Chemistry.
Topical term or geographic name as entry element Bioorganic chemistry.
Topical term or geographic name as entry element Biochemistry.
Topical term or geographic name as entry element Catalysis.
Topical term or geographic name as entry element Chemistry.
Topical term or geographic name as entry element Bioorganic Chemistry.
Topical term or geographic name as entry element Biochemistry, general.
Topical term or geographic name as entry element Medicinal Chemistry.
Topical term or geographic name as entry element Catalysis.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783642246319
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-3-642-24632-6
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type E-Book
Copies
Price effective from Permanent location Date last seen Not for loan Date acquired Source of classification or shelving scheme Koha item type Damaged status Lost status Withdrawn status Current location Full call number
2014-04-14AUM Main Library2014-04-14 2014-04-14 E-Book   AUM Main Library547
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