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03447nam a22004455i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20140310153332.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
120529s2012 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783642303289 |
|
978-3-642-30328-9 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QD410-412.5 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
547.05 |
| Edition number |
23 |
| 264 #1 - |
|---|
| -- |
Berlin, Heidelberg : |
| -- |
Springer Berlin Heidelberg : |
| -- |
Imprint: Springer, |
| -- |
2012. |
| 912 ## - |
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| -- |
ZDB-2-CMS |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Haber, Adi. |
| Relator term |
author. |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
Metallocorroles for Attenuation of Atherosclerosis |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
by Adi Haber. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIX, 87 p. 63 illus., 17 illus. in color. |
| Other physical details |
online resource. |
| 440 1# - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Springer Theses, Recognizing Outstanding Ph.D. Research, |
| International Standard Serial Number |
2190-5053 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Biologically relevant ROS/RNS -- Atherosclerosis -- The pro-atherogenic role of LDL and macrophages -- The anti-atheroginicity of HDL -- Common treatments for atherosclerosis -- Corroles -- Catalytic antioxidants -- Electronic spectra -- Research Goals -- Results -- Interactions of corroles with lipoproteins -- Corrole-lipoproteins binding -- Corrole distribution in serum -- Spectral changes in the presence of lipoprotein components -- The effect of corroles on oxidative-stress-induced lipoprotein damage -- Cu+2-induced oxidation -- Peroxynitrite-induced oxidation -- Lipoprotein function -- Interactions of corroles with macrophages -- Fluorescence-based detection of 1-Ga -- Chemiluminescence-based detection of 1-Fe -- Cellular accumulation of 1-Fe versus iron(III) porphyrins -- The effect of corroles on macrophage atherogenicity -- Effect on oxidative-stress-induced cell death -- Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis -- Discussion -- Interaction of corroles with lipoproteins -- Corrole distribution in serum -- Mode of 1-Fe binding to lipoproteins -- Materials and Methods. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Chemistry. |
|
|---|
| Topical term or geographic name as entry element |
Medicine. |
|
|---|
| Topical term or geographic name as entry element |
Chemistry, Organic. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry. |
|
|---|
| Topical term or geographic name as entry element |
Chemistry. |
|
|---|
| Topical term or geographic name as entry element |
Organometallic Chemistry. |
|
|---|
| Topical term or geographic name as entry element |
Biochemistry, general. |
|
|---|
| Topical term or geographic name as entry element |
Biomedicine general. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Display text |
Printed edition: |
| International Standard Book Number |
9783642303272 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-642-30328-9 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
E-Book |
