From the content: Parallel Spectral Clustering for the segmentation of cDNA Microarray Images -- Prognostic prediction using clinical expression time series: Towards a supervised learning approach based on meta-biclusters -- Parallel e-CCC-Biclustering: Mining approximate temporal patterns in gene expression time series using parallel biclustering -- Identification of regulatory binding sites on mRNA using in vivo derived informations and SVMs -- Parameter influence in genetic algorithm optimization of support vector machines.

The growth in the Bioinformatics and Computational Biology fields over the last few years has been remarkable.. The analysis of the datasets of Next Generation Sequencing needs new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Also Systems Biology has also been emerging as an alternative to the reductionist view that dominated biological research in the last decades. This book presents the results of the  6th International Conference on Practical Applications of Computational Biology & Bioinformatics held at University of Salamanca, Spain, 28-30th March, 2012 which brought together interdisciplinary scientists that have a strong background in the biological and computational sciences.