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Targeting Functional Centers of the Ribosome

by Davidovich, Chen.
Authors: SpringerLink (Online service) Series: Springer Theses Physical details: XIV, 74 p. online resource. ISBN: 3642169317 Subject(s): Life sciences. | Chemistry, Organic. | Nucleic acids. | Biochemistry. | Life Sciences. | Nucleic Acid Chemistry. | Protein Science. | Organic Chemistry.
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E-Book E-Book AUM Main Library 572.84 (Browse Shelf) Not for loan

Introduction -- Methods -- Results -- Discussion.

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

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