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Phosphodiesterases as Drug Targets

by Francis, Sharron H.
Authors: Conti, Marco.%editor. | Houslay, Miles D.%editor. | SpringerLink (Online service) Series: Handbook of Experimental Pharmacology, 0171-2004 ; . 204 Physical details: XVIII, 522 p. online resource. ISBN: 364217969X Subject(s): Medicine. | Toxicology. | Biochemistry. | Enzymes. | Post-translational modification of proteins. | Cytology. | Biomedicine. | Pharmacology/Toxicology. | Medicinal Chemistry. | Protein Structure. | Enzymology. | Posttranslational Modification. | Cell Physiology.
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E-Book E-Book AUM Main Library 615 (Browse Shelf) Not for loan

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

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