Epidemiology and biology: Rencal cell cancer (RCC) epidemiology. Pathology of RCC. Molecular biology of RCC. Prognostic and predictive biomarkers -- Clinical considerations: Clinical presentation and staging -- Surgical and local control modalities: Surgical approaches to early stage RCC. Palliative debulking nephrectomy in advanced stage RCC. Metastasectomy. Energy ablative techniques in RCC. Radiation therapy in RCC -- Systemic therapy considerations: Cytokines and other immune therapies in RCC. Anti-VEGF therapy in RCC. The role of mTOR inhibitors and PI3K pathway blockade in RCC. Sequential versus combination strategies. Presurgical therapy. Toxicity management for patients on targeted therapy. Emerging agents in RCC.

Kidney Cancer: Principles and Practice is an interdisciplinary textbook that encompasses all clinically relevant aspects of the disease and is designed to be as user-friendly as possible in order to meet the needs of the busy practitioner. To this end, the informative text is complemented by helpful boxed sections that present essential ‘take home’ points and patient-oriented cases demonstrating the clinical application of elements discussed in the chapter in question. Original high-quality images, some in color, are included whenever necessary to simplify particularly complex material. The authors are an international group of acknowledged experts in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others. This clinically oriented volume will be of great interest to clinicians, researchers, residents, and fellows, as well as to students and knowledgeable lay people.