Library of American University of Madaba
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Davidovich, Chen.
Targeting Functional Centers of the Ribosome [electronic resource] / by Chen Davidovich. - XIV, 74 p. online resource. - Springer Theses .
Introduction -- Methods -- Results -- Discussion.
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
9783642169311
Life sciences.
Chemistry, Organic.
Nucleic acids.
Biochemistry.
Life Sciences.
Nucleic Acid Chemistry.
Protein Science.
Organic Chemistry.
QD433-436
572.84
Targeting Functional Centers of the Ribosome [electronic resource] / by Chen Davidovich. - XIV, 74 p. online resource. - Springer Theses .
Introduction -- Methods -- Results -- Discussion.
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
9783642169311
Life sciences.
Chemistry, Organic.
Nucleic acids.
Biochemistry.
Life Sciences.
Nucleic Acid Chemistry.
Protein Science.
Organic Chemistry.
QD433-436
572.84