Library of American University of Madaba
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Evaluation of drug candidates for preclinical development : pharmacokinetics, metabolism, pharmaceutics, and toxicology /
edited by Chao Han, Charles B. Davis, Binghe Wang.
- Hoboken, N.J. : Wiley, 2010.
- x, 289 p., [2] p. of plates : ill. (some col.) ; 25 cm.
- Wiley series in drug discovery and development .
Includes bibliographical references and index.
Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Ramesh Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, and Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.
9780470044919 (cloth)
Drug development.
Pharmacokinetics.
Drugs--Metabolism.
Drug Evaluation, Preclinical.
Drug Discovery.
Drug Industry--standards.
Pharmaceutical Preparations--metabolism.
Pharmacology--methods.
RM301.25
615.19 / E93
Includes bibliographical references and index.
Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Ramesh Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, and Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.
9780470044919 (cloth)
Drug development.
Pharmacokinetics.
Drugs--Metabolism.
Drug Evaluation, Preclinical.
Drug Discovery.
Drug Industry--standards.
Pharmaceutical Preparations--metabolism.
Pharmacology--methods.
RM301.25
615.19 / E93